Lymphedema Clinical Trials
Here are the 6 most popular medical studies for lymphedema
Behavioural Intervention
Complete Decongestive Therapy (CDT) for Facial Swelling
Injuries to the face caused by traumatic events such as motor vehicle collisions, assault, and falls can result in facial trauma, which can result in swelling and disfiguration that impairs the important functions of the face, sometimes to a life threatening degree. These injures and the resultant swelling can also precipitate psychological and social consequences. Lymphedema is an abnormal amount of fluid that causes swelling, usually in the arms or legs. The most common presentation of lymphedema is in the upper extremities due to breast cancer treatment (Maclellean RA et al). As such, standards of care for management of lymphedema are primarily derived from the cancer research literature and involve the extremities (Moffatt CJ. 2003 QJM). The current gold standard treatment for patients with extremity lymphedema is complete decongestive therapy (CDT) (Zuther 2013). CDT is a multimodal therapy consisting of four components: manual lymph drainage, compression wrapping, exercise, and skin care (Zuther 2013).These same therapeutic techniques of CDT have been employed at Our Lady of the Lake Regional Medical Center (OLOLRMC) and adapted to treat patients with facial trauma with anecdotally good results primarily related to cosmesis. To the best of our knowledge, no clinical studies examining the effect of lymphedema treatment in the management of blunt facial trauma currently exist.. Beyond the consideration of cosmesis, we also seek to determine if this intervention improves clinical outcomes such as time to swallowing and reduced time utilizing mechanical ventilation. This study will prospectively evaluate the use of complete decongestive therapy to test the hypothesis that this intervention results in improved clinical outcomes in patients with blunt facial trauma.
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Lymphedema Clinical Trials With No Placebo
View 38 lymphedema medical studies that do not have a placebo group.
CDT Management for Head and Neck Cancer-Related Lymphedema
This trial will compare two different treatments for cancer-related lymphedema - one given in a clinic setting and one given at home. They will compare how well each treatment works, based on measures of lymphedema severity, symptoms, functional status, and healthcare utilization.
Behavioral Intervention
Swimming for Post-Breast Cancer Surgery Complications
This trial will study if physical activity, specifically swimming, can reduce post-surgery swelling and fluid build-up that cause pain and reduce quality of life for breast cancer patients.
View More Lymphedema Trials
See another 19 medical studies focused on lymphedema.
Frequently Asked Questions
Introduction to lymphedema
What are the top hospitals conducting lymphedema research?
Lymphedema, a condition characterized by swelling in the arms or legs due to lymphatic system dysfunction, is being actively addressed by top hospitals across the United States and Canada. M D Anderson Cancer Center in Houston leads the way with three ongoing lymphedema trials and an overall record of four completed trials. This renowned institution embarked on its first lymphedema trial in 2012, demonstrating their commitment to finding effective treatments for this debilitating condition. In Nashville, Vanderbilt University Medical Center has made significant contributions as well, currently conducting two active trials for lymphedema and having completed five previous studies since initiating their inaugural trial in 2015.
Further north at Edmonton's Cross Cancer Institute, researchers are vigorously exploring new avenues to combat lymphedema through two active clinical trials while holding a solid track record of five historical investigations dating back to 2003- when they first began focusing specifically on this condition. Meanwhile,Olive View-University of California Los Angeles Medical Center situated at Sylmar has joined forces with dedication towards tackling current challenges; it is hosting two progressive experiments dealing with Lymphoedemas.Their journey started relatively recently compared to others around ten years ago from now (in 2012). Lastly but not least important Stanford University based out of Stanford has also dedicated itself towards addressing Lymphoedeams ; displaying efforts through concurrent participation withintwo promising investigational ventures; theirs can be traced back till2009
With these prestigious institutions paving the way forward, there is hope on the horizon for those living with lymphedema. Each trial conducted brings us closer to understanding this complex condition better and developing innovative approaches that could alleviate symptoms and enhance patients' quality of life. By working together across different locations, these top hospitals exemplify how collaborative research efforts have the potential to make lasting impacts on healthcare worldwide
Which are the best cities for lymphedema clinical trials?
When it comes to lymphedema clinical trials, several cities are at the forefront of research and development. Columbus, Ohio leads with 8 active trials focusing on quality-of-life assessment and imaging techniques. Houston, Texas follows closely behind with 6 ongoing studies exploring annual lymphedema screening and vascularized lymph node transfer. Additionally, Newark, Delaware; Des Moines, Iowa; and Wichita, Kansas each have 6 or 5 active trials examining various aspects of quality-of-life assessment. These cities offer individuals affected by lymphedema opportunities to participate in cutting-edge clinical trials that advance our understanding and treatment options for this condition.
Which are the top treatments for lymphedema being explored in clinical trials?
Clinical trials are paving the way for advancements in lymphedema treatment, with several top contenders currently under exploration. Quality-of-Life Assessment takes the lead with its focus on improving patients' well-being and is currently being tested in two active clinical trials. Another promising option is the Advanced Pneumatic Compression Device (APCD), which aims to provide effective relief through compression therapy and is undergoing evaluation in one ongoing trial. Additionally, researchers are investigating an ultrasound procedure as a potential treatment option for lymphedema, with one active trial exploring its efficacy. These innovative approaches hold promise for improving the management of lymphedema and enhancing patients' quality of life.
What are the most recent clinical trials for lymphedema?
Exciting advancements are being made in the field of lymphedema treatment, with several recent clinical trials showcasing promising outcomes. One such trial focuses on advanced pneumatic compression for lymphedema, aiming to enhance patient management and alleviate symptoms associated with this condition. Additionally, a study explored the use of microbubble contrast agent Lumason as a potential therapeutic approach for lymphedema patients. Another trial investigated the efficacy of acebilustat in managing lymphedema symptoms at Phase 2 level. Furthermore, two Phase 3 trials assessed prophylactic lymphaticonvenous anastomosis and locoregional radiation treatment-hypofractionation as potential strategies to combat lymphedema's impact on patients' lives. These groundbreaking studies offer hope for improved treatments and better quality of life for individuals affected by lymphedema.
What lymphedema clinical trials were recently completed?
Recently completed clinical trials have made significant strides in the field of lymphedema treatment. Notably, a trial exploring the efficacy of Uproleselan, conducted by Washington University School of Medicine, concluded successfully. Additionally, a trial sponsored by the National Cancer Institute (NCI) investigated the potential benefits of mRNA-1273 therapy and reached completion. These efforts highlight ongoing advancements in addressing lymphedema and offer hope for patients seeking improved therapies for this condition.