Ketogenic Diet for Traumatic Brain Injury
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether a ketogenic diet (a high-fat, low-carb diet) can improve brain function after a traumatic brain injury (TBI). People with moderate to severe TBI often face long-term challenges with thinking and memory, and no proven medicine currently addresses this. The trial compares two groups: one follows a ketogenic or modified Atkins diet, and the other follows a regular diet. It is open to individuals who have recently suffered a TBI and are receiving treatment at Loma Linda University's surgical intensive care unit. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could lead to new dietary interventions for TBI recovery.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that the ketogenic or modified Atkins diet is safe for individuals with traumatic brain injury?
Research has shown that the ketogenic diet, high in fats and low in carbohydrates, might benefit people with traumatic brain injury (TBI). Early results suggest that adults generally tolerate this diet well.
In one study involving adults with TBI, participants followed a ketogenic diet without major safety concerns. Some individuals might experience fatigue or headaches when starting the diet, but these effects typically subside as the body adjusts.
Overall, evidence suggests that adults with TBI can safely follow the ketogenic diet, although individual experiences may vary.12345Why are researchers excited about this trial?
The ketogenic diet is unique because it shifts the body's metabolism from burning carbohydrates to burning fats, producing compounds called ketones. Researchers are excited about this approach for traumatic brain injury (TBI) because ketones might provide a more efficient energy source for the brain, potentially improving recovery. Unlike standard treatments that focus on managing symptoms or preventing further brain damage, the ketogenic diet targets the brain's energy supply directly, offering a novel way to support healing.
What evidence suggests that a ketogenic diet might be an effective treatment for traumatic brain injury?
This trial will compare the effects of different diets on recovery from traumatic brain injury (TBI). Participants in one arm of the trial will follow a ketogenic/modified Atkins diet, which is high in fat and low in carbohydrates. Studies have shown that this diet may aid recovery by altering the body's energy source, leading to ketone production, which may help the brain heal. Research suggests that ketosis, where the body uses fat for energy instead of carbohydrates, could address energy issues in the brain after a TBI. Some early studies indicate that this diet might protect the brain and enhance thinking and memory. While more research is needed, the ketogenic diet shows promise in aiding TBI recovery. Participants in another arm will follow a standard diet for comparison.12346
Who Is on the Research Team?
Duc Tran, MD
Principal Investigator
Loma LInda University Medical Center
Brenda Bartnik-Olson, PhD
Principal Investigator
Loma LInda University Medical Center
Are You a Good Fit for This Trial?
This trial is for individuals with moderate to severe traumatic brain injury (TBI) admitted to Loma Linda University's surgical intensive care unit. Eligible participants are those within 2-30 days post-injury but not pregnant, without severe speech issues, significant prior neurological disorders or interventions, acute intoxication at the time of injury, certain metabolic disorders that conflict with a ketogenic diet, history of serious mental illness, renal failure, abdominal surgery during admission, Type 1 diabetes or liver dysfunction.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a ketogenic or modified Atkins diet to assess its impact on neurocognitive and neurological outcomes
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessments of cognitive and neurological outcomes
What Are the Treatments Tested in This Trial?
Interventions
- Ketogenic Diet
- Ketogenic/Modified Atkins Diet
- Standard Diet
Find a Clinic Near You
Who Is Running the Clinical Trial?
Loma Linda University
Lead Sponsor