Milk Thistle for Body Dysmorphic Disorder

Phase-Based Progress Estimates
University of Chicago, Chicago, ILBody Dysmorphic DisorderMilk Thistle - Drug
18 - 65
All Sexes
What conditions do you have?

Study Summary

This trial will study the effects of milk thistle on 15 people, divided into two 4-week phases with a one-week break in between. One phase will have the participants taking milk thistle, and the other phase will have them taking a placebo. The trial will be double-blind, meaning neither the participants nor the researchers will know which group is taking the milk thistle until the trial is over.

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 4 Secondary · Reporting Duration: Baseline and 9 weeks

Baseline and 9 weeks
Clinical Global Impression- Severity and Improvement (CGI)
Hamilton Anxiety Rating Scale (HAM-A)
Hamilton Depression Rating Scale (HAM-D)
Sheehan Disability Scale (SDS)
Yale Brown Obsessive Compulsive Scale Modified for Body Dysmorphic Disorder (BDD-YBOCS)

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Side Effects for

Milk Thistle
This histogram enumerates side effects from a completed 2020 Phase 2 trial (NCT02473913) in the Milk Thistle ARM group. Side effects include: Nausea with 17%, Bloating with 6%, Headaches with 6%, Insomnia with 6%.

Trial Design

2 Treatment Groups

Silymarin (Milk Thistle)
1 of 2
1 of 2

Experimental Treatment

Non-Treatment Group

2 Treatment Groups

Primary Treatment: Milk Thistle · Has Placebo Group · Phase 2

Silymarin (Milk Thistle)
Experimental Group · 1 Intervention: Milk Thistle · Intervention Types: Drug
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Drug
First Studied
Drug Approval Stage
How many patients have taken this drug
Milk thistle
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: baseline and 9 weeks

Who is running the clinical trial?

University of ChicagoLead Sponsor
935 Previous Clinical Trials
754,134 Total Patients Enrolled
Jon E Grant, JD, MD, MPHPrincipal InvestigatorUniversity of Chicago
7 Previous Clinical Trials
877 Total Patients Enrolled

Eligibility Criteria

Age 18 - 65 · All Participants · 3 Total Inclusion Criteria

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Who else is applying?

What state do they live in?
North Carolina100.0%
How old are they?
18 - 65100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%

Frequently Asked Questions

What is the participant capacity for this research endeavor?

"Affirmative, displays that this investigation is actively recruiting candidates. Initially advertised on October 1st 2016, the trial necessitates 15 participants to be recruited at one location." - Anonymous Online Contributor

Unverified Answer

Is this particular trial the inaugural study of its type?

"Currently, two trials for milk thistle are ongoing in multiple cities and countries. The first experiment took place in 2009, sponsored by Madaus Inc., with 140 participants making it through Phase 2 & 3 of the drug approval process. Since then, 18337 studies have been conducted." - Anonymous Online Contributor

Unverified Answer

Who can participate in this clinical trial?

"Only those with body dysmorphic disorder and aged between 18-65 are eligible to participate in this research. 15 individuals need to be enrolled into the study." - Anonymous Online Contributor

Unverified Answer

Does this trial currently have open enrollment?

"Per the information on, this trial is proactively seeking volunteers. The original posting was made on October 1st 2016 and the entry has since been updated November 2nd 2022." - Anonymous Online Contributor

Unverified Answer

To what ailments is Milk Thistle typically prescribed?

"Milk Thistle is regularly administered to treat NASH, and can also provide relief from hepatitis, long-term cirrhosis of the liver, and nonalcoholic fatty liver disease." - Anonymous Online Contributor

Unverified Answer

Has the FDA sanctioned Milk Thistle for medical use?

"Milk thistle has only been through two rounds of clinical testing, suggesting that the safety level is approximately a 2. Unfortunately, there is not yet any evidence to indicate its efficacy." - Anonymous Online Contributor

Unverified Answer

Does this trial permit those aged eighty-five and above to participate?

"This clinical trial has an age requirement of 18 to 65, whereas there are 4 separate trials for those younger and 8 for those older." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.