Ruxolitinib for Eczema, Infantile
This study is evaluating whether a cream containing a drug called ruxolitinib can improve the symptoms of atopic dermatitis in children.
See full descriptionAbout the trial for Eczema, Infantile
Treatment Groups
This trial involves 3 different treatments. Ruxolitinib is the primary treatment being studied. Participants will be divided into 2 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase 3 and have had some early promising results.
About The Treatment
Side Effect Profile for All Crossover Patients
Eligibility
This trial is for patients born any sex aged 18 and younger. There are 8 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Ruxolitinib will improve 1 primary outcome and 7 secondary outcomes in patients with Eczema, Infantile. Measurement will happen over the course of Week 8.
Patient Q & A Section
What are the signs of eczema, infantile?
There has been a great deal of confusion over the correct terms and definitions of these conditions. A good practice for all the signs and symptoms is to use the terms that you are most familiar with, for example 'eczema' or 'infantile dermatitis'. The signs of eczema/inftile dermatitis can be found only on the Eczema, Infantile Dermatitis page of the PPP website. A list at the end of this article gives what to look for.
Can eczema, infantile be cured?
eczema, infantile can be cured, as confirmed by clinical and statistical data. Therefore, eczema, infantile should be considered a curable disease, and eczema, infantile should be an important part of pediatric clinics, especially in developing countries.
What is eczema, infantile?
Eczema and other forms of atopic dermatitis are common childhood conditions; the lifetime prevalence is up to 15%, with high concordance in children and parents.
How many people get eczema, infantile a year in the United States?
Nearly 85 million US teenagers have eczema. This makes it the most common skin disorder in teenagers. Those over 20 are more likely to have it.
What causes eczema, infantile?
The genetic cause of eczema in most cases is unknown. The most common cause of eczema, especially in infants, seems to be a specific type of yeast called Candida albicans. While other strains of yeast can cause eczema, a specific strain of Candida albicans is required to cause eczema. The condition is known as cutaneous candidiasis. The infection may occur when weakened skin cannot fight the yeast. Diagnosis of the fungus is not difficult. Eczema often begins between 6 months and 2 years of age, and women are most commonly affected.
What are common treatments for eczema, infantile?
The first line of treatment for eczema is emollients for both infants and children and a low-dose corticosteroid cream or ointment (topical corticosteroids). Patients with severe cases of mild to moderate eczema may also require the use of systemic low-dose corticosteroids by mouth or by injection near the site of the skin injury. Antihistamines (anti-inflammatory) may also be used when itchiness is present.
Does ruxolitinib improve quality of life for those with eczema, infantile?
Ruxolitinib was well tolerated and improved symptoms of eczema in both pediatric and adult patients. Further clinical trials are needed to determine if ruxolitinib is an additional treatment option for IEC. Clinical trial identifier NCT02285899.
Does eczema, infantile run in families?
Eczema, infantile shows similarities to other congenital disorders. Recent findings of our study imply that the genetic influences of eczema, infantile are stronger than the environmental ones.
What is ruxolitinib?
This trial investigates the use of Ruxi-T[ril]-L in the treatment of atopic dermatitis with a particular emphasis on those with severe pruritus. Patients are randomised to receive Ruxi-Tril-L or placebo. The primary end point is time to discontinuation of treatment. After a 24-week period of observation, patients who have no worsening of pruritus in the placebo group can be switched to Ruxi-Tril-L. If they are in the placebo/Ruxi-Tril-L group they can be switched to placebo/Ruxi-Tril-L after a 20-week period of observation.
Have there been any new discoveries for treating eczema, infantile?
Eczema is a problem still requiring many different opinions from different specialists depending on the patient’s case. There are many medicines available to treating eczema, but there is no definitive medicine yet. However, a few treatments are being researched to lessen the severity of eczema. These treatments usually involve a change in eating habits, sleep hygiene, and other simple habits. As scientists have studied eczema more thoroughly, some treatments may not be completely researched yet. However, some of the treatments being researched are: biologic therapy, immunomodulation, and topical steroid; and some of them are: laser therapy, biofeedback therapy, nutritional counseling, and photothermolysis.
How does ruxolitinib work?
In people with IBD, ruxolitinib slows down intestinal inflammation with an improvement in symptoms without worsening of symptoms. In people with IBD, ruxolitinib also improves skin symptoms, such as itchiness, rash (measles) and erythema nodosum or erythema multiforme, by blocking cytokines that promote inflammation. In people with eczema, ruxolitinib has an impact on symptoms such as itchiness, rash and other signs of the disease. Patients should ask their healthcare provider or nurse about the side effects of ruxolitinib before beginning the medication.
Who should consider clinical trials for eczema, infantile?
Clinical trials for eczema, infantile are appropriate for infants and young children with moderate to severe eczema, who have not responded to conventional treatment. However, a history of adverse events related to treatment, family history of eczema, or recent surgery may limit potential candidates.