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Janus Kinase (JAK) Inhibitor

Ruxolitinib cream for Atopic Dermatitis

Phase 1
Waitlist Available
Research Sponsored by Incyte Corporation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1, weeks 2, 4 and 8
Awards & highlights

Study Summary

This trial is testing if a drug called ruxolitinib is safe and tolerated when applied topically to kids with atopic dermatitis. They will also be testing to see if the drug has any adverse effects when absorbed into the body.

Eligible Conditions
  • Atopic Dermatitis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1, weeks 2, 4 and 8
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1, weeks 2, 4 and 8 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of treatment-emergent adverse events
Secondary outcome measures
Accumulation ratio of Ruxilitinib
Concentration of Ruxolitinib in plasma
Plasma Css of Ruxolitinib

Trial Design

1Treatment groups
Experimental Treatment
Group I: Ruxolitinib creamExperimental Treatment1 Intervention
ruxolitinib 1.5% cream will be applied twice daily to all areas of the skin affected by AD
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ruxolitinib cream
2022
Completed Phase 3
~1850

Find a Location

Who is running the clinical trial?

Incyte CorporationLead Sponsor
364 Previous Clinical Trials
55,136 Total Patients Enrolled
Innovaderm ResearchUNKNOWN
1 Previous Clinical Trials
40 Total Patients Enrolled
Haq Nawaz, MD, MPH, MBA, MSStudy DirectorIncyte Corporation

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are currently enrolled in this clinical research endeavor?

"This medical study is no longer accepting participants, having first been posted on December 16th 2021 and last updated July 29 2022. Should you be seeking other studies related to eczema or infantile conditions, there are currently 235 trials for the former and 97 for Ruxolitinib cream actively recruiting patients."

Answered by AI

Are there any other experiments involving the topical application of Ruxolitinib?

"Ruxolitinib cream was first used in a study conducted at National Institutes of Health Clinical Center, 9000 Rockville Pike back in 2002. Since then, 91 trials have been completed and the current slate consists of 97 active ones with many based out of Gresham Oregon."

Answered by AI

How many outposts are managing this research project?

"Volunteers can join this trial in 16 different locations, such as Cyn3Rgy Research - Clinedge - Ppds based in Gresham, Orange County Research Center located in Anaheim and San Marcus Research Clinic Inc. established at Miami Lakes."

Answered by AI

Does this clinical trial accept participants under the age of 35?

"Following the eligibility requirements of this research, children aged two to eleven are suitable for recruitment."

Answered by AI

Has the Food and Drug Administration accredited Ruxolitinib cream?

"Due to its Phase 1 status, there is limited evidence surrounding the safety and efficacy of Ruxolitinib cream. Our team at Power assigned it a score of 1 on our scale from one to three."

Answered by AI

Is this research experiment currently recruiting participants?

"This clinical trial has closed its recruitment phase; it was first posted on December 16th 2021 and the site's most recent update occured on July 29th 2022. However, there are currently 235 trials actively enrolling patients with eczema symptoms and 97 studies for Ruxolitinib cream searching for participants to join."

Answered by AI

What conditions does Ruxolitinib cream typically ameliorate?

"Ruxolitinib cream is a commonly prescribed remedy for polycythemia vera, as well as hydroxyurea-resistant or -intolerant primary myelofibrosis and other forms of polycythemia."

Answered by AI

Which demographic is allowed to take part in this medical experiment?

"This study has 29 openings for children aged between two and eleven who are afflicted with eczema. To be considered, they must meet the following criteria: male or female 2-11 year old (age at time of screening), an active condition persisting for three months prior to enrollment in the trial, a score of 4+ on Itch NRS during screening period if 6-11 years old; 35% severity rating based on EASI scale at both baseline and screening visits; target lesion that measures ≥5 cm2 located anywhere except face, hands, feet or genitalia; discontinue all other treatments used for AD from start"

Answered by AI

Who else is applying?

What state do they live in?
Florida
How old are they?
65+
What site did they apply to?
Forward Clinical Trials
What portion of applicants met pre-screening criteria?
Met criteria
~9 spots leftby Apr 2025