← Back to Search

Dietary Nitrate

Beet Juice for Sickle Cell Anemia

Phase 2
Waitlist Available
Led By Natalia Dixon, MD
Research Sponsored by Wake Forest University Health Sciences
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up days 1, 14, 28
Awards & highlights

Study Summary

The investigators hypothesize that increasing plasma nitrite using dietary nitrate will improve platelet function and red cell deformability and decrease MCHC in patients with sickle cell disease. The investigators will test this hypothesis through administration of daily intake of beetroot juice (Unbeetable - Performance Drink) to patients with sickle cell disease for 28 days. The investigators will evaluate the safety of daily beet root juice intake in patients with sickle cell disease. In addition, the investigators will measure MCHC, red cell deformability, and platelet function (activation and aggregation) in response to daily intake of beet root juice in this patient population.

Eligible Conditions
  • Sickle Cell Anemia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~days 1, 14, 28
This trial's timeline: 3 weeks for screening, Varies for treatment, and days 1, 14, 28 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Total Number of Participants with Adverse Events as a Measure of Safety and Tolerability as a function of time
Secondary outcome measures
Changes in Platelet function as a function of time
Changes in Red blood cell properties as a function of time

Trial Design

1Treatment groups
Experimental Treatment
Group I: Beet JuiceExperimental Treatment1 Intervention
Volunteers will drink a single 8 ounce bottle of beet juice (Unbeetable) per day for 28 days. On days 1,14, and 28, the juice will be drunk just prior to having blood drawn. Blood will also be drawn 1.5 hours after drinking the juice on days 1,14, and 28.

Find a Location

Who is running the clinical trial?

Wake Forest UniversityOTHER
190 Previous Clinical Trials
164,600 Total Patients Enrolled
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,847 Previous Clinical Trials
47,818,646 Total Patients Enrolled
25 Trials studying Sickle Cell Anemia
2,458 Patients Enrolled for Sickle Cell Anemia
Wake Forest University Health SciencesLead Sponsor
1,244 Previous Clinical Trials
1,004,806 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Study of Beet Juice for Patients With Sickle Cell Anemia
2014. "Study of Beet Juice for Patients With Sickle Cell Anemia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02162225.
~0 spots leftby May 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top