Laser for Alopecia

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
University of Minnesota, Minneapolis, MN
Alopecia+3 More
Laser - Device
Eligibility
18+
Male
What conditions do you have?
Select

Study Summary

This study is evaluating whether a laser can help improve hair growth for individuals with male pattern hair loss.

See full description

Eligible Conditions

  • Alopecia
  • Androgenetic Alopecia (AGA)
  • Male Pattern Hair Loss

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Laser will improve 4 primary outcomes and 2 secondary outcomes in patients with Alopecia. Measurement will happen over the course of Week 0, end of trial (8-16 weeks).

Week 16
Hair Growth Assessment (HGA)
Hair Growth Index (HGI)
Week 8
Change in Hair Growth Satisfaction Scale (HGSS)
Change in Scalp Symptom Assessments
Week 16
Change in Additional Investigator Global Assessment of Photography
Change in Investigator Global Assessment of Photography

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

4 Treatment Groups

Treatment A
1 of 4
Safety Group
1 of 4
Treatment B
1 of 4
Placebo
1 of 4
Experimental Treatment
Non-Treatment Group

This trial requires 48 total participants across 4 different treatment groups

This trial involves 4 different treatments. Laser is the primary treatment being studied. Participants will be divided into 3 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.

Treatment A
Drug
Laser: Fractional ablative, deep mode, 5% fractional coverage Post-Laser Minoxidil 2%: 2ml of 20mg/ml sterile solution, applied post-laser procedure
Safety Groupwill participate in one visit, receiving laser assisted delivery of minoxidil and PK data. The safety group treatments will follow dose escalation as follows: Safety Participant 1: Post-laser 5mg minoxidil (0.25ml of 20mg/ml sterile solution, applied post-laser procedure) Safety Participant 2: Post-laser 10mg minoxidil (0.5ml of 20mg/ml sterile solution, applied post-laser procedure) Safety Participant 3: Post-laser 20mg minoxidil (1mL of 20mg/mL sterile solution, applied post-laser procedure)
Treatment BLaser: Fractional ablative, deep mode, 5% fractional coverage Post-Laser Minoxidil 2%: 2ml of 20mg/ml sterile solution, applied post-laser procedure At-Home Minoxidil 5%: 2ml of 50mg/ml foam q24 h for duration of study
Placebo
Device
Laser: Fractional ablative, deep mode, 5% fractional coverage Post-Laser Saline 0.9%: 2ml of sterile saline solution applied post-laser procedure
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Laser
2008
Completed Phase 4
~2170

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: week 0, week 4(+4), week 8(+4)
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly week 0, week 4(+4), week 8(+4) for reporting.

Closest Location

University of Minnesota - Minneapolis, MN

Eligibility Criteria

This trial is for male patients aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
I am willing to abstain from using non-steroidal anti-inflammatory medications, aspirin, St show original
, I was curious to know if there was a major difference using the honey-based product show original
People who participate in a study must be able to understand what they are consenting to, and must be capable of making an informed decision. show original
A person with MPHL has been diagnosed by a board-certified dermatologist. show original
Males ages 21-65 years old with MPHL
Norwood III vertex-V. The vertex scalp must be involved
Willing to adhere to protocol, including scalp examinations and photography

Patient Q&A Section

What causes alopecia?

"The etiology of alopecia is still not fully understood. A variety of theories and hypotheses as to the cause of alopecia have been explored with varying degrees of success. Nevertheless, the most prevalent hypothesis is that one or more genetic defects disrupt the normal functions of the hair follicle and/or the hair shaft. However, it is difficult to reconcile the rarity of alopecia with that observed with other inherited genetic disorders." - Anonymous Online Contributor

Unverified Answer

What is alopecia?

"Alopecia is the permanent loss of hair. It can be divided into three types: Androgenetic or male Pattern hair loss, Female Pattern hair loss, and Telogen effluvium. Male Pattern hair loss is often associated with prostate disease or systemic diseases (Autoimmune diseases, Cushing's Syndrome, Diabetes Mellitus, Hepatitis C, Hypothyroidism or other autoimmune diseases), and telogen effluvium is the simplest type of hair loss. It can be reversed by applying the correct medications, and it is almost completely treatable (if not treated, the result is permanent hair loss)." - Anonymous Online Contributor

Unverified Answer

What are the signs of alopecia?

"The patient usually shows signs of scalp hair loss after age 6 or 8. Hair loss begins at the front and midline and spreads outward. Affected areas can be itchy, tender, or painful. The patient usually shows signs of hair loss in the following areas: eyebrows, cheeks, scalp, forehead, or sides of face. The hair loss can sometimes be dramatic.\n" - Anonymous Online Contributor

Unverified Answer

What are common treatments for alopecia?

"Common treatment approaches for alopecia include topical products, and oral medications like minoxidil; these options, however, produce minimal effect. Hair transplantation is a potential solution that allows patients to regain hair follicle density and volume in a short time span." - Anonymous Online Contributor

Unverified Answer

How many people get alopecia a year in the United States?

"There are more women with androgalactoeal pruritus than men. The most common subtypes of alopecia are diffuse alopecia and androgen-responsive alopecia in women and male pattern alopecia; no difference seen in women's and men's alopecia of all types. There are statistically significant disparities by race and ethnicity in the types of alopecia seen amongst men and women." - Anonymous Online Contributor

Unverified Answer

Can alopecia be cured?

"It is difficult to ascertain if the cure for alopecia is a cure at all. Some theories have been proposed that suggest the cause of the hair loss or atrophy may be related to the pathology of the disease. However, there are still no verified treatments that have produced permanent hair regrowth or new hair growth.\n" - Anonymous Online Contributor

Unverified Answer

Has laser proven to be more effective than a placebo?

"Laser treatment is a valid treatment to reduce the symptoms of androgenic alopecia, and has long-term results. The use of combined treatments (laser and steroidal) has been shown to be more effective than steroid-only treatment." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in laser for therapeutic use?

"Laser light treatment should be thought of as a surgical technique but a light source and equipment designed for the purpose is always necessary. There is an excellent chance of cure and a good chance of restoring normal hair growth after laser treatment, if this is the goal. Laser treatments using argon laser and a 585 nm CO laser are the most effective. In our case, the argon laser at 870 nm was also very successful but we only had enough energy for one treatment" - Anonymous Online Contributor

Unverified Answer

How does laser work?

"While most people can regain most of their hair after laser treatment a good initial trim to expose the bald patches before treatment is recommended." - Anonymous Online Contributor

Unverified Answer

How serious can alopecia be?

"Men may perceive their loss of hair as being more severe than it may actually be; thus, they may be less willing to discuss the topic of hair loss with physicians." - Anonymous Online Contributor

Unverified Answer

Does alopecia run in families?

"Patients with alopecia areata should be questioned about possible family history of the condition after the doctor identifies possible signs of the disease. This helps to identify patients who could be at risk for the development of alopecia areata at an earlier stage." - Anonymous Online Contributor

Unverified Answer

What does laser usually treat?

"The main effect of laser is the reduction of the size and number of hairs, but there are no reports of hair regrowth. However, if there is a co-morbidity, laser treatment may help to control itching and lessen other symptoms. Because hair regrowth is a temporary effect of laser, patients may sometimes have to use their own hair to cover up scars. The effect of laser treatment on male pattern hair loss has not been published. Therefore, some may experience a worsening of symptoms at first, but all patients should be informed that the initial symptom is to regress in 1–2 months." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
See if you qualify for this trial
Get access to this novel treatment for Alopecia by sharing your contact details with the study coordinator.