Ultrasound for Evaluating Muscle Health in Cancer Patients

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: M.D. Anderson Cancer Center

Disqualifiers: Non-English, Neurological compromise, Unstable condition, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Approved in 3 Jurisdictions This treatment is already approved in other countries

Compensation: Varies

Number of Visits: 2

Duration: 1 day

20 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial studies how well an ultrasound procedure (non-invasive MuscleSound technology) can be used to learn about levels of glycogen (a type of sugar) in cancer patients during inpatient rehabilitation. The ultrasound information will be processed to represent the energy storage in the muscle. The energy storage in the muscle may help future research to look for dietary plans that can help to increase energy storage, patient exercise tolerance, and functional improvement.

Who Is on the Research Team?

Ying Guo, MD

Principal Investigator

M.D. Anderson Cancer Center

Are You a Good Fit for This Trial?

This trial is for cancer patients with or without cachexia, which involves significant weight loss. Participants must be able to consent and follow study procedures, have a record of their weight or BMI from the past 6 months, and be undergoing physical therapy-led rehabilitation. Excluded are those unable to understand instructions, non-English speakers, patients with unstable medical conditions that limit exercise participation, or those with neurological issues causing muscle atrophy in both lower extremities.

Inclusion Criteria

My weight or BMI has been recorded in the last 6 months.

I have a confirmed solid tumor and can move at least one of my legs.

I have lost more than 5% of my weight in the last 6 months without trying, or I've lost over 2% with a BMI under 20.

Exclusion Criteria

I can understand and follow the study's instructions.

I don't have any health conditions that stop me from doing leg exercises.

I have muscle loss in both legs due to nerve damage.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Baseline Assessment

Baseline glycogen storage and other baseline measures are assessed using ultrasound and other tools

1 day

1 visit (in-person)

Treatment

Participants undergo ultrasound via MuscleSound technology and physical therapy sessions

1 day

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Ultrasound

Trial Overview The trial is testing how well ultrasound technology (MuscleSound) can measure muscle glycogen levels in cancer patients during rehab. The goal is to use this data for future research on dietary plans and exercises that could improve energy storage in muscles and enhance patient recovery.

How Is the Trial Designed?

Group I: Device feasibility (MuscleSound technology) Experimental Treatment 3 Interventions

Patients undergo ultrasound via MuscleSound technology over 3 minutes at baseline and immediately after each of 2 physical therapy sessions comprising cycling or walking over 10 minutes.

Who Is Running the Clinical Trial?

M.D. Anderson Cancer Center

Lead Sponsor

Trials

3,107

Recruited

1,813,000+

National Cancer Institute (NCI)

Collaborator

Trials

14,080

Recruited

41,180,000+