Constant Routine Protocol for Circadian Rhythms

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Circadian Rhythms+1 More
Constant Routine Protocol - Other
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

This trial looks at how well central and peripheral circadian mechanisms work in Blacks with dipping and non-dipping systolic blood pressure.

Eligible Conditions
  • Circadian Rhythms
  • Blood Pressures

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

5 Primary · 2 Secondary · Reporting Duration: Expression of Bmal1 and Period 3 during a 30-hour constant routine protocol

Core body temperature amplitude during a 30-hour constant routine protocol
Core body temperature amplitude
Core body temperature phase during a 30-hour constant routine protocol
Core body temperature phase
Cortisol amplitude during a 30-hour constant routine protocol
Cortisol amplitude
Cortisol phase during a 30-hour constant routine protocol
Cortisol phase
Expression of Bmal1 and Period 3 during a 30-hour constant routine protocol
Buccal cell mRNA expression
Melatonin amplitude during a 30-hour constant routine protocol
Melatonin amplitude
Melatonin phase during a 30-hour constant routine protocol
Melatonin phase

Trial Safety

Safety Progress

1 of 3

Trial Design

1 Treatment Group

Constant Routine Protocol
1 of 1
Experimental Treatment

40 Total Participants · 1 Treatment Group

Primary Treatment: Constant Routine Protocol · No Placebo Group · N/A

Constant Routine Protocol
Other
Experimental Group · 1 Intervention: Constant Routine Protocol · Intervention Types: Other

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: expression of bmal1 and period 3 during a 30-hour constant routine protocol

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,419 Previous Clinical Trials
2,217,625 Total Patients Enrolled
American Heart AssociationOTHER
281 Previous Clinical Trials
5,823,730 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 2 Total Inclusion Criteria

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About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 17th, 2021

Last Reviewed: October 9th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.