Sulforaphane for Aging Problems

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Northern Arizona University, Flagstaff, AZ
Aging Problems
Sulforaphane - DietarySupplement
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This study is evaluating whether a combination of phytonutrients and exercise will improve the exercise response in older individuals.

See full description

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Aging Problems

Study Objectives

This trial is evaluating whether Sulforaphane will improve 1 primary outcome and 3 secondary outcomes in patients with Aging Problems. Measurement will happen over the course of Comparing trials separated by one week (supplement vs. placebo).

Comparing trials separated by one week (supplement vs. placebo)
Glutathione reductase (GR) gene expression in response to acute exercise
HO-1 gene expression in response to acute exercise
NQO1 gene expression in response to acute exercise
Nrf2 activation in response to acute exercise

Trial Safety

Safety Progress

1 of 3

Other trials for Aging Problems

Trial Design

2 Treatment Groups

SFN supplement
1 of 2
Placebo
1 of 2
Experimental Treatment
Non-Treatment Group

This trial requires 30 total participants across 2 different treatment groups

This trial involves 2 different treatments. Sulforaphane is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

SFN supplementThe oral sulforaphane supplement is a myrosinase-active whole broccoli sprout material (EnduraCell Bioactive, Cell-Logic, Queensland, AU) containing 14 mg SFN per capsule. Three capsules will be consumed 90 min prior to the start of the acute exercise trial. The dose of 3 capsules is equivalent to approximately 220 µmol of SFN, which is comparable to that of other studies using broccoli sprout extracts and the recommended single dose.
PlaceboPlacebo capsules provided by Cell-Logic.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Placebo capsules
2015
Completed Phase 3
~4330
Sulforaphane
2016
Completed Phase 3
~330

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: comparing trials separated by one week (supplement vs. placebo)
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly comparing trials separated by one week (supplement vs. placebo) for reporting.

Closest Location

Northern Arizona University - Flagstaff, AZ

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Successful completion of screening
Men: ≤ 30.5 mL/kg/min
This means that the lowest average blood flow for women is 21.2 mL/kg/min. show original
Men and women, 60 years and older
Competent to independently give informed consent

Patient Q&A Section

What causes aging problems?

"The aging process itself is more nuanced than one-dimensional. Although there are many factors affecting aging, the aging process is also influenced by an individual's genetic makeup, environment, and personality factors. This could be a new perspective on aging studies." - Anonymous Online Contributor

Unverified Answer

What are the signs of aging problems?

"Most of the signs in this section occur due to a systemic process instead of any particular condition. However, individuals with certain conditions may have additional signs and symptoms.\n" - Anonymous Online Contributor

Unverified Answer

What is aging problems?

"Almost half of the community-dwelling elderly used health services because they needed them. Half of them had several health problems, which can decrease life satisfaction." - Anonymous Online Contributor

Unverified Answer

What are common treatments for aging problems?

"Osteoporosis is commonly treated with medical or mechanical support, medication, and physical therapy. Other medical problems or diagnoses commonly treated are asthma, diabetes or diabetes complications, cardiovascular problems, and memory problems. Common treatments for aging problems may vary depending on the medical or mental health history of the patient. In addition, older adults may need services to deal with personal care needs and changes to physical structures as they grow older." - Anonymous Online Contributor

Unverified Answer

How many people get aging problems a year in the United States?

"Almost half of Americans experience functional limitation and are disabled. Approximately 5.8 million new cases of disability will occur a year in the United States." - Anonymous Online Contributor

Unverified Answer

Can aging problems be cured?

"Aging problems cannot be cured. People may wish to delay them for self-preservation and they are inevitable events. However, it is possible to postpone some problems such as osteoarthritis and to reduce disability and other morbidity. If a cure for aging-related problems is found, it would be more difficult to establish a cure for aging problems itself." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets aging problems?

"We found an average age of 67.3 years for men and 68.0 years for women with aging problems in an unselected general population survey. This mean age is in variance with those reported previously for men and women in an American sample, and should be adjusted to other population types." - Anonymous Online Contributor

Unverified Answer

Has sulforaphane proven to be more effective than a placebo?

"Even two doses of sulforaphane is more effective than a placebo at improving markers of inflammation and health-related quality of life. However, the high doses that were more effective in this study have not been used in any clinical trials." - Anonymous Online Contributor

Unverified Answer

Is sulforaphane typically used in combination with any other treatments?

"The majority of patients with advanced-ageing have been receiving sulforaphane therapy in combination with other known medical treatments. Despite a variety of clinical benefits, patients have not seen a significant survival benefit." - Anonymous Online Contributor

Unverified Answer

What is sulforaphane?

"Sulforaphane is a plant-derived flavonoid that has been found to have anti-inflammatory/anti-cancer activity in clinical researches and is under active research to find whether it can be used as a drug to prevent cognitive decline in aging or, alternatively, as a nootropic to improve cognitive abilities. To date, there has not been enough evidence in humans to conclusively prove this, but research is being done to test and establish Sulforaphane's efficacy and safety in this application. \n\nIn 2019, Canadian researcher, Prof. Robert S. Scovill, received $9." - Anonymous Online Contributor

Unverified Answer

What is the latest research for aging problems?

"Over the last 15 years, there has been a lot of research conducted that tries to find the best way to improve people's aging process. But some of the research hasn't been very effective or conclusive proof of their findings. To summarize, the latest research for aging is [the way to slow, stop, and possibly even reverse aging by manipulating genes (p. 12) by targeting stem cells (p. 12). That is exactly what we are wondering and looking for in modern age therapies. And that's why we're going to read up on the newest research at [AgeWatch.org]. (See References (AgeWatch.org) for current research on stem cells and aging. (https://www.agewatch." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of aging problems?

"The data suggest that the majority of people who suffer from age-associated difficulties have problems with mental health and/or physical mobility but that their overall physical and mental functions are not significantly impaired. Nevertheless, further research into the causes and underlying mechanisms of aging problems is necessary." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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