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estriol for Multiple Sclerosis

Phase 2
Waitlist Available
Led By Rhonda Voskuhl, M.D.
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Study Summary

This study is evaluating whether a hormone pill may help improve cognitive function in women with multiple sclerosis.

Eligible Conditions
  • Multiple Sclerosis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change from baseline in cognitive function assessed by Paced Serial Addition Test (PASAT).
Secondary outcome measures
Change from baseline in cognitive function as assessed by a brief battery of cognitive tests.
Change from baseline in cognitive function as assessed by cognitive evoked potentials, measured in milliseconds.
Change from baseline in standard MS outcome measures.
+1 more

Side effects data

From 2017 Phase 2 trial • 61 Patients • NCT02413008
6%
Urinary tract infection
2%
Lymphoma
100%
80%
60%
40%
20%
0%
Study treatment Arm
0.005% Estriol Vaginal Gel
Placebo Vaginal Gel

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Group A: EstriolExperimental Treatment2 Interventions
Standard MS Treatment + Estriol
Group II: Group B: PlaceboPlacebo Group2 Interventions
Standard MS Treatment + Placebo
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Norethisterone
FDA approved
Estriol
FDA approved

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,533 Previous Clinical Trials
10,265,518 Total Patients Enrolled
7 Trials studying Multiple Sclerosis
285 Patients Enrolled for Multiple Sclerosis
Rhonda Voskuhl, M.D.5.01 ReviewsPrincipal Investigator - University of California, Los Angeles
University of California, Los Angeles
2 Previous Clinical Trials
168 Total Patients Enrolled
2 Trials studying Multiple Sclerosis
168 Patients Enrolled for Multiple Sclerosis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition
Rhonda Voskuhl 2011. "Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01466114.
All > Primary Progressive Multiple Sclerosis
~5 spots leftby May 2025
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