This trial is evaluating whether Treatment will improve 6 primary outcomes and 5 secondary outcomes in patients with Opioid Abuse. Measurement will happen over the course of Change from baseline to discharge, up to 24 hours.
This trial requires 18 total participants across 2 different treatment groups
This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
With correct treatment, most drug abusers regain control and/or reduction in usage. However, significant numbers of individuals never successfully achieve remission of drug use. Current addiction treatment programs are under-utilized.
The symptoms of opioid overdose that are most common are gastrointestinal and neurological. More subtle signs of opioid abuse are likely to manifest with the duration of heroin use.\n
Frequent treatments for opioid abuse include medical and dental care, psychological counseling, and medication-assisted treatment or naloxone. These treatments may be utilized by nonhealth professionals to help patients overcome their opioid dependence.
Opioid abuse is a highly prevalent and potentially under-recognized problem that is associated most with heroin use and misuse, especially for the poor. Many more people experience heroin use and overdose of other opioids through prescription/over-the-counter prescription drugs than other street drugs.
It is more important to identify causes of opioid abuse, than to treat only the abuse itself. Opioid use may be increased by genetic susceptibility, stress responses to physical pain and exposure to stressful events such as natural disasters and wars.
About 10% of men and 10-22% of women in the United States misuse opioids. More than 3 million opioid abusers will have an overdose in the year 2010.
The majority of patients are not taking more than one other drug for the treatment of acute severe illness. Despite this, there was no consistent use of guideline-recommended treatments. The role of the clinical pharmacist during patients' hospitalizations should be explored, as pharmacokinetics and pharmacodynamics do not account for all interactions.
There have been many studies that have been published with the topic titled “Opioid abuse.” However, this research focuses on the symptoms, causes, and treatments for both illicit and medical opioid abuse rather than the prevention of it. It is very important that clinicians and addicts learn as much information as possible about how to deal with opioid abuse to help them recover. There are different prevention methods that have been found to help prevent this, although they have not been thoroughly studied.
Although there is not a consensus about the average age of onset of opioid abuse, our study shows that opioid use has increased over time. The number of patients on methadone and buprenorphine increased in parallel with the number of patients age 20 years or older on a opioid maintenance treatment. This finding may imply that opioid dependence has become more prevalent over time.
Treatment of opioid abuse is associated with improvement in HRQL. If validated the findings of this pilot study suggest the HRQL effects could potentially have implications beyond improved quality of life.
A total of 6 trials have been published since [the last review for a minimum of 10 years] using opioid-based drugs as treatment for chronic, moderate to severe pain. Several of these studies may be helpful in further [treatment] choices. However, none are specifically tailored to either opioid-based or co-mixed-mixed opioid use. One of the two trials is specifically geared toward a co-mixed-mixed use population, though it has yet to be submitted for publication (http://www.researchgate.
Opioid overdoses are a significant health problem, and urgent and effective intervention is needed. The rate of fatal overdoses is more than 10 times higher than for any other drug, and deaths are more common in elderly women than in other populations. While the risk of overdose death increases with age, the risk of overdose death is significantly greater in people aged less than 40 years who are abusing opioids than in people aged 70 years or older who are abusing opioids.