← Back to Search

Antiseptic

Povidone-iodine 0.5% antiseptic mouth rinse for COVID-19

Phase 2
Waitlist Available
Led By Patricia Corby, DDS, MS
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5, 30, 60 minutes post intervention
Awards & highlights

Study Summary

This study is a two-arm, randomized, 2-phase study. Phase I will be double blinded clinical trial of the safety and efficacy of an antiseptic mouthwash solution on reducing SARS-CoV-2 load in COVID 19+ adult individuals. Phase II is designed as an open label trial, and all subjects will receive the active mouthwash.

Eligible Conditions
  • COVID-19
  • Coronavirus

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5, 30, 60 minutes post intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5, 30, 60 minutes post intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
[PCR Saliva] Percent Change From Baseline Ct Viral Targets
Secondary outcome measures
[PCR Saliva] Percent Change From Baseline Cycle Threshold at 5 and 30 Minutes Post Intervention
Other outcome measures
[Nasal Swab] Log10 Antigens
[Oropharyngeal Swab] Percent Change From Baseline Log10 Antigens

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Povidone-iodine 0.5% antiseptic mouth rinseExperimental Treatment1 Intervention
Subjects will be asked to rinse/gargle one time with 10 mL of Povidone-iodine 0.5% antiseptic mouth rinse for 30 seconds.
Group II: PlaceboPlacebo Group1 Intervention
Subjects will be asked to rinse/gargle one time with 10 mL of placebo mouth rinse for 30 seconds.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Mouth rinse
2022
Completed Phase 2
~40

Find a Location

Who is running the clinical trial?

University of PennsylvaniaLead Sponsor
2,002 Previous Clinical Trials
42,880,959 Total Patients Enrolled
32 Trials studying COVID-19
6,273,977 Patients Enrolled for COVID-19
This study was funded by an Investigator Initiated Research grant from Avrio Health L.PUNKNOWN
Patricia Corby, DDS, MSPrincipal InvestigatorUniversity of Pennsylvania
1 Previous Clinical Trials
19 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Povidone-Iodine Oral Rinse Study
2022. "Povidone-Iodine Oral Rinse Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05239598.
~13 spots leftby Apr 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top