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Ozone for Asthma

N/A
Recruiting
Led By Michael Koehle, MD PhD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measured at baseline and 5 minutes after each exercise bout
Awards & highlights

Study Summary

This trial will show if people with asthma can adapt to ozone exposure by repeatedly exposing them to it.

Eligible Conditions
  • Asthma
  • Exercise-Induced Asthma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measured at baseline and 5 minutes after each exercise bout
This trial's timeline: 3 weeks for screening, Varies for treatment, and measured at baseline and 5 minutes after each exercise bout for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in FEF25-75 from baseline to 10 minutes after exercise
Change in FEV1 from baseline to 10 minutes after exercise
Change in FVC from baseline to 10 minutes after exercise
Secondary outcome measures
Change in Fraction of exhaled nitric oxide (FeNO) from baseline to 5 minutes after exercise
Change in Pulse Wave Velocity (PWV) from baseline to 20 minutes after exercise

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Ozone (O3) groupExperimental Treatment2 Interventions
Participants of the experimental group will perform sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling 170ppb ozone delivered continuously during each exercise session.
Group II: Filtered AirPlacebo Group2 Interventions
Participants of the sham group will also perform sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer similar to intervention. However, only in this group, the ozone generator will not be activated so that just filtered air will be delivered to the participant while performing each exercise session.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Exercise
2016
Completed Phase 1
~760

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,413 Previous Clinical Trials
2,466,921 Total Patients Enrolled
16 Trials studying Asthma
3,756 Patients Enrolled for Asthma
Michael Koehle, MD PhDPrincipal InvestigatorProfessor

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are presently enrolled in this research project?

"Affirmative. The clinical trial, which was originally listed on January 1st 2021 is currently seeking participants; data hosted by clinicaltrials.gov confirms this fact. 40 individuals will be recruited from two distinct medical centres for the study's duration."

Answered by AI

What are the prerequisites for joining this research project?

"To be eligible for this clinical trial, the patient must have exercise-induced bronchospasm and occupy an age range between 18 and 50. As of now, around 40 individuals are sought from the population."

Answered by AI

Are there any remaining slots for this medical experiment?

"Clinicaltrials.gov records show that this medical trial, initially posted on January 1 2021 and last updated May 28 2022, is still open to patient recruitment."

Answered by AI

What is the primary objective of this investigation?

"The primary end-point of the study, assessed at baseline and 10 minutes after each exercise bout, is to measure changes in FEF25-75. The secondary outcomes include alterations in Fractional Exhaled Nitric Oxide (FeNO) as a non-invasive indicator for airway inflammation measured 5 minutes post exercise, along with Pulse Wave Velocity (PWV), which gauges arterial stiffness through velocity readings taken 20 minutes following the intervention."

Answered by AI

Are seniors aged 75 and above being accepted as participants of this research?

"The age parameters for this research initiative are 18 years old and below the half-century mark."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Adaptation to Ozone in Individuals With Asthma/Exercise-induced Bronchoconstriction
Michael Koehle 2021. "Adaptation to Ozone in Individuals With Asthma/Exercise-induced Bronchoconstriction". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05105529.
~9 spots leftby Apr 2025
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