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Triple Drug Therapy for Kidney Cancer with Brain Metastases
Study Summary
This trial is testing the combination of three drugs to treat patients with renal cell carcinoma that has spread to the brain.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Media Library
- I have cancer that has spread to the lining of my brain and spinal cord.I have never had lung conditions like pulmonary fibrosis or pneumonitis.My side effects from cancer treatment are mild, except for hair loss.I do not have significant liver disease such as hepatitis or cirrhosis.I have not had severe infections or been hospitalized for them in the last 4 weeks.I agree to use effective birth control during and for 12 months after treatment.I need immediate brain surgery or radiation due to my cancer symptoms.The size of the tumor is between 5mm and 30mm, as seen on an MRI scan with a special dye.I haven't taken corticosteroids in the last 10 days, except for allowed exceptions.I have a specific type of blood cancer, such as acute leukemia or Burkitt lymphoma.You cannot have an MRI because you have a metal implant or are allergic to gadolinium contrast.I have had treatments for kidney cancer that has spread, but not with anti-CTLA-4, cabozantinib, or MET inhibitors.I have an autoimmune disease, but it's not one of the exceptions listed.I have not taken antibiotics in the last 2 weeks.I haven't had radionuclide therapy in the last 6 weeks.I do not have any health conditions that could interfere with the study treatment.I can take care of myself and am up and about more than half of the day.I need immediate surgery or radiation for cancer outside my brain.I have active tuberculosis.You are expected to live for more than 12 weeks.You are expected to live for less than 3 months.I haven't had cancer treatment in the last 4 weeks, except for some allowed therapies.You are allergic to synthetic human antibodies.I have a history of HIV or active hepatitis B/C, with an exception.I haven't had signs of infection in the last 2 weeks.I have not had any other cancers in the last 5 years.I have not received a live vaccine in the last 4 weeks and do not plan to during the study.I am 18 years old or older.My side effects from previous treatments are mild or gone.I have kidney cancer that has spread to my brain and can be measured.Your blood clotting tests should be within a certain range before you can join the study.I am not a candidate for immediate surgery or radiation for my condition.My recent blood tests show my organs are functioning well.I haven't had radiation for bone metastasis in the last 2 weeks or any other radiation in the last 4 weeks.I have brain-related symptoms that don't affect my daily activities and haven't taken steroids for 10 days.
- Group 1: Nivolumab
- Group 2: Ipilimumab
- Group 3: Cabozantinib
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has Nivolumab been tested for therapeutic efficacy in other studies?
"Currently, Nivolumab research is underway in 841 clinical trials, of which 94 are at Phase 3. Pittsburgh Pennsylvania plays a major role in this medical study, however there are many other sites operating across the world - 46024 locations to be exact."
How many volunteers are involved in this clinical experiment?
"Affirmatively, the details on clinicaltrials.gov reveal that recruitment for this medical study is still open. The trial was initially announced on September 20th 2022 and has been updated as recently as the same date. This research project requires 40 participants from one site in particular to be enrolled."
For what ailments is Nivolumab commonly prescribed?
"Nivolumab has been approved as a treatment for unresectable melanoma, and more recently it can be used to treat squamous cell carcinoma, high risk of recurrence, and other related diseases."
Is Nivolumab a safe and suitable treatment option for individuals?
"Our team at Power has awarded Nivolumab a score of 2 on its 1-3 scale due to the presence of clinical evidence confirming safety, but no data in regards to efficacy."
Is this research endeavor accepting participants at the moment?
"Affirmative. Research accessible on clinicaltrials.gov attests to the fact that this medical research, which was initially listed on September 20th 2022, is actively recruiting participants. A total of 40 patients are needed from a single location."
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