WAL0921 for Kidney Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new treatment, WAL0921, for individuals with certain kidney diseases that cause high protein levels in the urine, including diabetic kidney disease and some rare kidney conditions. The trial aims to determine if WAL0921 is safe and effective in reducing these protein levels compared to a placebo (a substance with no active medication). Participants will receive an infusion every two weeks for 14 weeks and will be monitored for 24 weeks after treatment ends. This trial may suit those diagnosed with diabetic nephropathy or specific rare kidney diseases who have not recently required dialysis. As a Phase 2 trial, the research focuses on measuring the treatment's effectiveness in an initial, smaller group of people.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.
Is there any evidence suggesting that WAL0921 is likely to be safe for humans?
Research has shown that WAL0921 is safe and generally well-tolerated by patients. In earlier studies, participants handled the treatment well, and researchers found no major safety issues. WAL0921 also effectively lowered certain proteins linked to kidney inflammation. While every treatment carries some risk, current evidence suggests that WAL0921 is a promising option for people with kidney diseases.12345
Why do researchers think this study treatment might be promising for kidney disease?
Researchers are excited about WAL0921 for kidney disease because it offers a novel approach compared to standard treatments like ACE inhibitors and ARBs. Unlike these traditional therapies, WAL0921 is administered intravenously, which could mean more precise delivery and potentially faster action. Additionally, WAL0921 may work through a different mechanism, offering hope for patients who do not respond well to current oral medications. This fresh angle not only holds promise for increased effectiveness but also expands treatment options for those with challenging cases of kidney disease.
What evidence suggests that WAL0921 might be an effective treatment for kidney disease?
Research has shown that WAL0921, which participants in this trial may receive, holds promise for treating kidney diseases. Studies have found that it effectively lowers suPAR, a protein linked to kidney inflammation and damage. By reducing suPAR levels, WAL0921 may help decrease excess protein in urine, a sign of kidney disease. Initial findings suggested that WAL0921 is safe and well-tolerated in patients. These results are encouraging for people with conditions like diabetic kidney disease and rare kidney disorders.13456
Who Is on the Research Team?
Andrew Blair, MD
Principal Investigator
Walden Biosciences
Are You a Good Fit for This Trial?
Adults aged 18-65 with certain kidney diseases (like diabetic nephropathy, primary FSGS, resistant minimal change disease, IgA nephropathy, or membranous nephropathy) and a minimum eGFR of 30 mL/min/1.73 m2 can join this study.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive the investigational drug WAL0921 or placebo as an intravenous infusion once every 2 weeks for 7 total infusions
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- WAL0921
Find a Clinic Near You
Who Is Running the Clinical Trial?
Walden Biosciences
Lead Sponsor