Study Summary
This trial is testing a vaccine to prevent COVID-19. It will study how safe and effective it is in adolescents, and will also study an optional booster dose.
- COVID-19
Treatment Effectiveness
Effectiveness Progress
Study Objectives
24 Primary · 22 Secondary · Reporting Duration: Part 3: Days 29 and 209
Trial Safety
Safety Progress
Trial Design
4 Treatment Groups
mRNA-1273
1 of 4
mRNA-1273 BD
1 of 4
mRNA-1273.222
1 of 4
Placebo
1 of 4
Experimental Treatment
Non-Treatment Group
4431 Total Participants · 4 Treatment Groups
Primary Treatment: mRNA-1273 · Has Placebo Group · Phase 2 & 3
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 12 - 18 · All Participants · 6 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Who else is applying?
What state do they live in?
| Florida | 29.5% |
| Illinois | 15.9% |
| Georgia | 11.4% |
| Other | 43.2% |
How old are they?
| 18 - 65 | 100.0% |
What portion of applicants met pre-screening criteria?
| Did not meet criteria | 84.1% |
| Met criteria | 15.9% |
Why did patients apply to this trial?
- "I was curious about new vaccines"
- "Want more research on covid and how to prevent it"
- "I feel there is an importance in helping out science."
- "Interested in participating in a trial. Just the name power is motivating."
- "I'm behind on my vaccines and would like to help test new vaccine if I am able"
How many prior treatments have patients received?
| 0 | 76.9% |
| 1 | 11.5% |
| 2 | 3.8% |
| 3+ | 7.7% |
What questions have other patients asked about this trial?
- "Are there any sites near me?"
- "What trials are available for me?"
What site did they apply to?
| Medpharmics - Albuquerque | 50.0% |
| Alliance for Multispecialty Research, LLC | 50.0% |
How responsive is this trial?
Typically responds via
| 100.0% | |
- Ali, Kashif, Gary Berman, Honghong Zhou, Weiping Deng, Veronica Faughnan, Maria Coronado-Voges, Baoyu Ding, et al.. 2021. “Evaluation of Mrna-1273 Sars-cov-2 Vaccine in Adolescents”. New England Journal of Medicine. Massachusetts Medical Society. doi:10.1056/nejmoa2109522.
- Ali, Kashif, Gary Berman, Honghong Zhou, Weiping Deng, Veronica Faughnan, Maria Coronado-Voges, Baoyu Ding, et al.. 2021. “Evaluation of Mrna-1273 Sars-cov-2 Vaccine in Adolescents”. New England Journal of Medicine. Massachusetts Medical Society. doi:10.1056/nejmoa2109522.
- 2020. "A Study to Evaluate the Safety, Reactogenicity, and Effectiveness of mRNA-1273 Vaccine in Adolescents 12 to <18 Years Old to Prevent COVID-19". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04649151.
Frequently Asked Questions
Is this clinical trial being conducted in multiple locations within the city?
"There are many locations participating in this clinical trial, but a few notable ones are Cottonwood Pediatrics in Hastings, Nebraska, Meridian Clinical Research (Omaha-Nebraska) - Platinum - PPDS in Omaha, South Carolina, and Meridian Clinical Research - Charleston, SC in Charleston." - Anonymous Online Contributor
Does this research involve any participants who are octogenarians or younger?
"This study is meant for children aged 12 to 18. Out of the 1,144 total clinical trials, this one falls in the 146 trials catering to those under 18 years old." - Anonymous Online Contributor
Is this research looking for new participants at the moment?
"Unfortunately, this particular study is not currently looking for participants. Although, it's worth noting that the trial was most recently updated on October 25th, 2020. There are 1119 other trials actively recruiting patients with covid-19 and 28 studies for mRNA-1273 that are still looking for volunteers." - Anonymous Online Contributor
What are the requirements for participants in this experiment?
"This clinical trial is recruiting 3931 people with covid-19 aged 12 and 18. Most importantly, applicants should meet the following criteria: • Participants 12 to <18 years of age at the time of consent (Screening Visit, Day 0) who, in the opinion of the Investigator, are in good general health based on review of medical history and screening physical examination., • Investigator assessment that the participant, in the case of an emancipated minor, or parent(s)/legally acceptable representative(s) [LAR(s)] understand and is willing and physically able to comply with protocol-" - Anonymous Online Contributor
How many guinea pigs are a part of this experiment?
"This trial is no longer recruiting patients. It was initially posted on December 9th, 2020 and last updated on October 25th, 2022. However, there are 1119 other trials related to covid-19 that are still admitting participants and 28 mRNA-1273 trials that are also currently enrolling patients." - Anonymous Online Contributor
Is this research project something new?
"Since 2020, mRNA-1273 has undergone extensive clinical trials. The first was sponsored by ModernaTX and took place in the same year. After involving 120 patients, it received Phase 1 approval in 2020. Currently, there are 28 active studies being conducted for this medication across 219 cities and 22 countries worldwide." - Anonymous Online Contributor
Are there other research projects that have used the mRNA-1273 vaccine?
"mRNA-1273 was first trialed in 2020 by the Kaiser Permanente Washington Health Research Institute - Vaccines and Infectious Diseases. So far, a total of 18295 completed trials have been conducted. There are presently 28 live clinical trials, with a large number taking place in Hastings, Nebraska." - Anonymous Online Contributor