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Nicotine for Nicotine Addiction

Phase < 1
Recruiting
Research Sponsored by University of Southern California
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
At least 21 years old
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0 hours after using the vaping device (right after)
Awards & highlights

Study Summary

This trial will explore how nicotine affects a person's response to rewards/punishments, with the aim of understanding nicotine addiction and the quitting process.

Who is the study for?
This trial is for adults over 21 who use nicotine at least once a month and can go without it for 10 hours before lab visits. They must speak English but cannot participate if they are pregnant, planning to become pregnant, or breastfeeding.Check my eligibility
What is being tested?
The study tests how nicotine affects Pavlovian bias in users by having them vape with and without nicotine before doing tasks that measure their reactions to rewards and punishments. Participants' performance on these tasks will be compared under the influence of nicotine versus no nicotine.See study design
What are the potential side effects?
While not explicitly listed, potential side effects from vaping with nicotine may include throat irritation, coughing, increased heart rate and blood pressure, dizziness, headaches, dry mouth or eyes.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am at least 21 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0 hours after using the vaping device (right after)
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0 hours after using the vaping device (right after) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Levels of Pavlovian Bias measured through a version of the Go/No-Go task

Side effects data

From 2014 Phase 4 trial • 127 Patients • NCT01400243
65%
Any nonserious adverse event
22%
Itchiness at Patch Site
16%
Nausea
8%
Redness at patch site
5%
Headache
5%
Decreased appetite
2%
Lucid dreams
2%
Hot or sweating
2%
Lightheadedness
100%
80%
60%
40%
20%
0%
Study treatment Arm
Nicotine Patch
Placebo Patch

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: NicotineExperimental Treatment1 Intervention
Participants will follow a standard vape protocol designed to deliver the approximate nicotine typically consumed from 1 cigarette (1.25 mg)
Group II: PlaceboPlacebo Group1 Intervention
Participants will follow a standard vape protocol that is equal inhalation to that used in the nicotine condition.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Nicotine
2005
Completed Phase 4
~2980

Find a Location

Who is running the clinical trial?

University of Southern CaliforniaLead Sponsor
906 Previous Clinical Trials
1,596,136 Total Patients Enrolled
3 Trials studying Vaping
1,186 Patients Enrolled for Vaping

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any enrollment opportunities for this clinical experiment?

"Sadly, as indicated on clinicaltrials.gov this trial is no longer recruiting patients; the initial posting was made September 1st 2023 and the most recent update was recorded August 30th of that same year. However, there are 118 other medical studies actively seeking participants currently."

Answered by AI

Who else is applying?

What site did they apply to?
University of Southern California
What portion of applicants met pre-screening criteria?
Met criteria

Why did patients apply to this trial?

I need to quit smoking.
PatientReceived no prior treatments

What questions have other patients asked about this trial?

How much do you get paid?
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Nicotine and Pavlovian Bias
John Robert Monterosso 2023. "Nicotine and Pavlovian Bias". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06027723.
~16 spots leftby Aug 2024
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