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Nicotine

Nicotine for Nicotine Addiction

Phase 1
Waitlist Available
Led By Mehmet Sofuoglu, M.D.,Ph.D.
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up over 3 hours
Awards & highlights

Study Summary

This trial is testing different doses of nicotine to see at what dose smokers can tell the difference from a placebo. Nicotine will be delivered via IV in doses that match how much would be delivered from smoking a cigarette. There will be four doses tested.

Eligible Conditions
  • Nicotine Addiction

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~over 3 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and over 3 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Drug Effect Questionnaire

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: NicotineActive Control1 Intervention
Experimental Session 2 will determine if smokers can discriminate 0.05, 0.025, and 0.0125 mg nicotine/pulse of nicotine from saline.
Group II: salinePlacebo Group1 Intervention
Saline will compared to different nicotine doses. Nicotine doses: 0.05, 0.025, and 0.0125 mg nicotine/pulse of nicotine from saline.

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,847 Previous Clinical Trials
2,737,657 Total Patients Enrolled
4 Trials studying Nicotine Addiction
194 Patients Enrolled for Nicotine Addiction
Mehmet Sofuoglu, M.D.,Ph.D.Principal InvestigatorYale University
8 Previous Clinical Trials
242 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any availability to join this research endeavor?

"This clinical trial is seeking 20 individuals with a diagnosis of tobacco dependence aged 21 to 65."

Answered by AI

What is the scope of participant recruitment for this trial?

"Affirmative. Clinicaltrials.gov has records that this medical research study, which was initially posted on February 16th 2022, is currently recruiting participants. A total of 20 individuals are required at one location for the trial to proceed."

Answered by AI

Are geriatric individuals being incorporated into this analysis?

"According to the inclusion criteria, eligible participants for this particular trial must fall between 21 and 65 years of age. Conversely, there are 8 trials dedicated solely to minors and 131 tailored towards those beyond senior-age."

Answered by AI

Is there availability for participation in this experiment?

"According to the recent update on clinicaltrials.gov, this medical experiment is still in need of applicants. It was initially posted publicly on February 16th 2022 and has since been amended April 12th 2022."

Answered by AI

What prior experiments have been conducted related to Nicotine?

"Currently, 71 Nicotine trials are active. Of the 5 Phase 3 studies underway, the majority of them are based in Green Bay, Wisconsin with an additional 204 locations hosting a trial for this drug."

Answered by AI

Is there a risk factor associated with Nicotine usage for patients?

"As this is a Phase 1 trial, there is limited data confirming Nicotine's safety and efficacy, thus it was assigned an estimated score of 1."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Nicotine Differences in Smokers
Mehmet Sofuoglu 2022. "Nicotine Differences in Smokers". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05159934.
~3 spots leftby Apr 2025
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