Electronic Hookah Inhalation (- nicotine) for Endothelial Dysfunction

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
UCLA, Westwood, CAEndothelial Dysfunction+1 MoreElectronic Hookah Inhalation (- nicotine) - Other
Eligibility
21 - 39
All Sexes
What conditions do you have?
Select

Study Summary

This trial will investigate the effects of e-hookah bowl inhalation on endothelial function and vascular biomarkers in young healthy hookah smokers.

Eligible Conditions
  • Endothelial Dysfunction
  • Smoking

Treatment Effectiveness

Effectiveness Progress

1 of 3

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e-hookah aerosol

Study Objectives

9 Primary · 0 Secondary · Reporting Duration: 30 minutes

30 minutes
Changes in biomarkers of oxidative stress and inflammation (8-iso-prostaglandin F2α)
Changes in biomarkers of oxidative stress and inflammation (fibrinogen)
Changes in biomarkers of oxidative stress and inflammation (oxidized LDL)
Inflammation
Changes in endothelial cell function
Changes in endothelial cell function (factor-ĸB)
Changes in endothelial cell function (nitric oxide)
Changes in endothelial cell function (nitrotyrosine)
Changes of Endothelial function

Trial Safety

Safety Progress

1 of 3

Similar Trials

1
Supplemented with B-Complex
1
Blueberry Powder
1
e-hookah aerosol

Trial Design

3 Treatment Groups

Vascular Endothelial Function
1 of 3
Vascular endothelial cells
1 of 3
Biomarkers of oxidative stress and inflammation
1 of 3

Experimental Treatment

18 Total Participants · 3 Treatment Groups

Primary Treatment: Electronic Hookah Inhalation (- nicotine) · No Placebo Group · N/A

Vascular Endothelial FunctionExperimental Group · 3 Interventions: Electronic Hookah Inhalation (- nicotine), Electronic Hookah Inhalation (+ nicotine), Sham Inhalation · Intervention Types: Other, Other, Other
Vascular endothelial cellsExperimental Group · 3 Interventions: Electronic Hookah Inhalation (- nicotine), Electronic Hookah Inhalation (+ nicotine), Sham Inhalation · Intervention Types: Other, Other, Other
Biomarkers of oxidative stress and inflammationExperimental Group · 3 Interventions: Electronic Hookah Inhalation (- nicotine), Electronic Hookah Inhalation (+ nicotine), Sham Inhalation · Intervention Types: Other, Other, Other

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 30 minutes

Who is running the clinical trial?

Tobacco Related Disease Research ProgramOTHER
22 Previous Clinical Trials
16,070 Total Patients Enrolled
University of California, Los AngelesLead Sponsor
1,423 Previous Clinical Trials
6,773,596 Total Patients Enrolled
5 Trials studying Endothelial Dysfunction
330 Patients Enrolled for Endothelial Dysfunction
Mary Rezk-Hanna, PhDPrincipal Investigator - University of California, Los Angeles
University of California, Los Angeles

Eligibility Criteria

Age 21 - 39 · All Participants · 9 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
Your heart rate should be less than 100 beats per minute while at rest.
You are not currently taking any prescription drugs.
You have never used illegal drugs.
You are between 21-39 years old and have smoked hookah more than 12 times in the last year.
You are between 21 and 39 years old and have used an e-cigarette more than 12 times in the last 12 months.
References

Frequently Asked Questions

Does this medical experiment accept participants aged 25 or older?

"According to the regulation of this medical experiment, only those between 21 and 39 years old are qualified. Additionally, 8 other studies focus on participants under 18 while 87 trials seek patients above 65." - Anonymous Online Contributor

Unverified Answer

Are there any specific requirements that must be met in order to join this medical trial?

"This clinical trial has limited its participants to those between 21 and 39 years old who are current smokers. A total of 18 individuals will be accepted for the study." - Anonymous Online Contributor

Unverified Answer

What is the size of this clinical research project?

"That is correct. The clinicaltrials.gov database indicates that recruitment for this trial, initially posted on November 1st 2019, is still underway. 18 participants are needed across a single site in total." - Anonymous Online Contributor

Unverified Answer

Is recruitment for this experiment open at present?

"According to clinicaltrials.gov, this trial is currently recruiting patients. It was first announced on November 1st 2019 and the most recent update was published on September 1st 2022." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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