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Electronic Cigarette Aerosol for Biomarkers

Phase < 1
Waitlist Available
Led By Felix W. Wehrli, Ph.D.
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
• BMI of 18.5 - 30
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to six hours
Awards & highlights

Study Summary

This trial will test the effects of nicotine-free electronic cigarette vapor on vascular function in healthy non-smokers.

Eligible Conditions
  • Endothelial Dysfunction
  • Biomarkers

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to six hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to six hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Aortic pulse-wave velocity (meters/second)
Breath hold index (meters/seconds^2)
Changes in serum protein levels (micrograms) of inflammatory biomarkers (HMGB-1, RAGE, ICAM, CRP) in non-smoking healthy subjects before and after electronic cigarette aerosol inhalation.
+4 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Healthy, Non-SmokersExperimental Treatment1 Intervention
Non-nicotinized electronic cigarette aerosol (16 2-second long puffs)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Electronic Cigarette Aerosol
2018
Completed Early Phase 1
~40

Find a Location

Who is running the clinical trial?

University of PennsylvaniaLead Sponsor
2,005 Previous Clinical Trials
42,882,202 Total Patients Enrolled
National Institutes of Health (NIH)NIH
2,701 Previous Clinical Trials
7,506,845 Total Patients Enrolled
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,838 Previous Clinical Trials
47,851,623 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Acute Effects of E-Cigarette Aerosol Inhalation
Felix W. Wehrli 2018. "Acute Effects of E-Cigarette Aerosol Inhalation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03479203.
~4 spots leftby Apr 2025
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