Naltrexone for Eating Disorders
This study is evaluating whether fMRI can be used to measure the effects of opioid antagonism in adolescents with eating disorders.
See full descriptionAbout the trial for Eating Disorders
Treatment Groups
This trial involves 2 different treatments. Naltrexone is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase < 1 and are in the first stage of evaluation with people.
About The Treatment
Side Effect Profile for Naltrexone + Supportive Counseling
Eligibility
This trial is for patients born any sex aged 65 and younger. There are 3 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Naltrexone will improve 1 primary outcome and 3 secondary outcomes in patients with Eating Disorders. Measurement will happen over the course of Study day 1.
Who is running the study
Principal InvestigatorPatient Q & A Section
What is eating disorders?
Results from a recent paper indicated that the risk of developing an eating disorder in a lifetime was higher than in other Western countries. Eating disorders are a heterogenous disorder in terms of symptoms and severity and prevalence rates differ from country to country. Although the etiology of eating disorders is not fully elucidated, a combination of genetic and environmental factors may play an important role in development.
What causes eating disorders?
Eating disorders must be suspected when a person exhibits at least three of the five following symptoms for at least two weeks: unexplained weight loss more than 10% in the preceding 12 months, concern about the appearance of their body, concern that they are not getting enough food, concern that the quality of food is not good enough, and concern with eating frequency. When the person does not want to eat they should visit their doctor. Dietitians can advise patients based on their particular health and circumstances, to develop healthy eating habits and coping techniques. Furthermore, psychotherapists can offer a range of interventions to make a recovery from an eating disorder a reality.
What are common treatments for eating disorders?
A number of medications, psychotherapy and the GI decontamination therapy are commonly used treatments for eating disorders. However, the use of medications for the treatment of eating disorders may be low.
How many people get eating disorders a year in the United States?
The percentage of women who have ED is higher than the percentage of men. For the first time, estimates of the number of cases of ED in the United States were made. The number of cases will continue to increase, especially among adolescents.
What are the signs of eating disorders?
Some common signs can be divided into eating-related (depression related to low mood), general (appetite loss), nutritional (weight loss, poor balance) and behavioral (self-destructive behavior). These symptoms will have different levels of severity and can be combined. Some signs can signal eating-disease related behaviors.\n
Can eating disorders be cured?
There is no evidence of a cure for anorexia nervosa or bulimia nervosa. There is some evidence that intensive and intensive-outpatient treatment are effective in achieving remission of anorexia nervosa.
Does naltrexone improve quality of life for those with eating disorders?
Naltrexone treatment was associated with improvements in a number of QoL domains and general QoL. These improvements were significant and were not explained by concurrent improvements in body mass index, depression, or binge eating.
What are the latest developments in naltrexone for therapeutic use?
Naltrexone is effective and well tolerated in treating individuals with opioid-dependent heroin users. Naltrexone may be an effective short-term treatment for opioid dependence, and may be considered as a treatment alternative to long-term abstinence.
What is the latest research for eating disorders?
It is critical to summarize and analyze the latest research for individuals seeking help or support related to eating disorders (EDs). These statistics will let the reader learn more about the current state of research for EDs and help make the best decisions regarding the course of treatment and monitoring of patients over time.
Does eating disorders run in families?
Many of the characteristics of ED-families identified in previous studies also appear to cluster together within family members. However, family members of ED-patients could be identified regardless of their own ED status. In a recent study, findings suggest that even if ED can only be detected at the patient level, there are still important family processes that need to be explored. Clinicians may benefit from incorporating specific assessment tools designed to help the family anticipate and manage ED.
Have there been other clinical trials involving naltrexone?
We searched PubMed in order to highlight other studies involving naltrexone and found that most trials are small and have not led to further development. There are currently two large clinical trials that are recruiting patients (see 'Affective Disorders and Related Disorders (AD/D)': ClinicalTrials.gov:http://clinicaltrials.gov/ct2/show/NCT00293650); (Affective Disorders and Related Disorders (AD/D): ClinicalTrials.gov:http://clinicaltrials.gov/ct2/show/NCT00293650)) and they have been under review by the FDA as of 2018.
Is naltrexone typically used in combination with any other treatments?
This review suggests that NRT treatment, as prescribed, is commonly used with many types of treatment for alcohol use disorders. The use of medication is generally found to be prescribed less frequently than NRT, and with relatively high rates of discontinuation. The findings from this review may provide useful information for other researchers interested in treatment of drinking disorders, so that treatment programs can be designed to optimize the benefit of prescription opioid treatment for alcohol use disorders with both naltrexone and medication prescribed.