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Methamphetamine for Stimulant Abuse (DDP Trial)

Phase < 1
Recruiting
Led By Harriet de Wit
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up time frame: day 1(baseline), 3
Awards & highlights

DDP Trial Summary

This trial will study how methamphetamine affects the brain's reward system by using fMRI.

Who is the study for?
This trial is for right-handed individuals with a Body Mass Index (BMI) between 19 and 26, who consume less than four alcoholic or caffeinated beverages daily. It's designed to study the effects of stimulant abuse.Check my eligibility
What is being tested?
The study tests the impact of methamphetamine versus a placebo on brain function related to reward processing. Participants will undergo fMRI scans to observe these effects.See study design
What are the potential side effects?
Methamphetamine can cause side effects like anxiety, insomnia, mood swings, increased heart rate and blood pressure, reduced appetite, and potential for dependency.

DDP Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~time frame: day 1(baseline), 3
This trial's timeline: 3 weeks for screening, Varies for treatment, and time frame: day 1(baseline), 3 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in SUbjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Sub-scales of Drug Effects Questionnaire (DEQ).

Side effects data

From 2021 Phase 1 trial • 8 Patients • NCT04178993
50%
Elevated Heart Rate
50%
Elevated Blood Pressure
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo Comparator: Placebo
Active Comparator: Duloxetine (60 mg)

DDP Trial Design

2Treatment groups
Experimental Treatment
Group I: Placebo Then MethamphetamineExperimental Treatment2 Interventions
Participants first receive placebo at their first session in the laboratory. Then will return to the laboratory 72 hours later and will receive 20 mg methamphetamine.
Group II: MethamphetamineThen PlaceboExperimental Treatment2 Interventions
Participants first receive 20 mg methamphetamine at their first session in the laboratory Then will return to the laboratory 72 hours later and will receive placebo.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Methamphetamine
2013
Completed Phase 1
~130
placebo oral tablet
2021
Completed Early Phase 1
~80

Find a Location

Who is running the clinical trial?

University of ChicagoLead Sponsor
997 Previous Clinical Trials
817,538 Total Patients Enrolled
Harriet de WitPrincipal InvestigatorPrincipal Investigator
6 Previous Clinical Trials
221 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has Methamphetamine been previously tested in any similar experiments?

"Presently, there are 5 investigations into Methamphetamine's efficacy in progress with none of them yet reaching the final phase. 8 different clinical sites across the country have been recruited to participate in these trials; most notably within Chicago, Illinois."

Answered by AI

Could I be considered a suitable candidate for this medical trial?

"For this clinical trial, 160 right-handed patients aged 18 to 35 with a BMI between 19 and 26 who currently use stimulants are needed. Additionally, they must consume fewer than 4 alcoholic or caffeinated beverages each day."

Answered by AI

What is the total number of individuals receiving treatment from this trial?

"Affirmative, the clinical trial is actively seeking out qualified participants. It was initially advertised on November 1st 2020 and last revised on October 20th 2022; it aims to recruit 160 people from a single medical centre."

Answered by AI

Are there any open enrollments for this clinical experiment?

"Affirmative. Records hosted on clinicaltrials.gov imply that this medical experiment is currently recruiting patients. This trial, which was first posted in November 2020, needs to enroll 160 individuals from one site for completion."

Answered by AI

Is there an age requirement that restricts the enrollment of this research study?

"This experiment has a minimum age limit of 18 and an upper bound of 35, as stated in the requirements for patient inclusion."

Answered by AI

Who else is applying?

What state do they live in?
Indiana
What site did they apply to?
University of Chicago
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
1
~37 spots leftby Mar 2025