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Non-Invasive Screening Methods for Down Syndrome

N/A

Waitlist Available

Led By Mary E. D'Alton, M. D.

Research Sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Women 16 to 45 years old

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

Study Summary

This trial will compare the accuracy of several non-invasive tests for Down syndrome.

Who is the study for?

This trial is for pregnant women aged 16 to 45, enrolled before 10-14 weeks of pregnancy. They must understand English or have an interpreter and be generally healthy, though some existing conditions are allowed. Women with multiple pregnancies cannot participate.Check my eligibility

What is being tested?

The study compares several non-invasive tests in the first and second trimesters with invasive methods like amniocentesis to diagnose Down Syndrome. It involves 38,000 women across 11 centers to determine which screening method is most accurate.See study design

What are the potential side effects?

Since this trial focuses on non-invasive screening methods for Down Syndrome, there are no direct side effects from the interventions being studied as they do not involve drugs or medical procedures that affect the body like surgeries.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am a woman aged between 16 and 45.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Lead Sponsor

1,963 Previous Clinical Trials

2,636,741 Total Patients Enrolled

Mary E. D'Alton, M. D.Principal InvestigatorColumbia-Presbyterian Hospital Medical Center

Media Library

Treatment Clinical Trial Eligibility Overview. Trial Name: NCT00006445 — N/A

Chromosome Abnormalities Research Study Groups:

Chromosome Abnormalities Clinical Trial 2023: Treatment Highlights & Side Effects. Trial Name: NCT00006445 — N/A

Treatment 2023 Treatment Timeline for Medical Study. Trial Name: NCT00006445 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there an opportunity to join this clinical experimentation?

"This research is recruiting 38000 people with down syndrome in the age bracket of 16 to 45. Female participants need to be healthy, though they may still have other medical conditions."

Answered by AI

Are senior citizens being considered as participants in this research endeavor?

"The prerequisites for this medical trial are that patients must be between 16 and 45 years old. For reference, there are 384 trials available to minors under 18 and 987 clinical studies open to those above 65."

Answered by AI

How many healthcare facilities are participating in this experiment?

"Ten medical centres are currently enrolling participants for this trial, including sites in Bronx and Seattle. To reduce the strain of travel on volunteers, it is recommended that they select the closest location to their residence."

Answered by AI

Recent research and studies

Journal of Medical ScreeningJournal

Antenatal Screening for Down's Syndrome

Wald, Nicholas J, Anne Kennard, Allan Hackshaw, and Ali McGuire. 1997. “Antenatal Screening for Down's Syndrome”. Journal of Medical Screening. SAGE Publications. doi:10.1177/096914139700400402.

Seminars in PerinatologyJournal

SURUSS in Perspective‡

Wald, N.J., C. Rodeck, A.K. Hackshaw, and A. Rudnicka. 2005. “SURUSS in Perspective‡”. Seminars in Perinatology. Elsevier BV. doi:10.1053/j.semperi.2005.05.006.

clinicaltrials.govStudy

Down Syndrome - Comparison of Screening Methods in the 1st and 2nd Trimesters

2024. "Down Syndrome - Comparison of Screening Methods in the 1st and 2nd Trimesters". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00006445.

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