CLINICAL TRIAL

Nicotine (electronic cigarette) for Smoking, Cigarette

Recruiting · 18+ · All Sexes · Providence, RI

Using ANDS to Reduce Harm for Low SES Cigarette Smokers

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About the trial for Smoking, Cigarette

Eligible Conditions
Smoking, Cigarette · Tobacco Use Disorder · Nicotine Dependence

Treatment Groups

This trial involves 2 different treatments. Nicotine (electronic Cigarette) is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
Nicotine (nicotine pouch)
OTHER
Experimental Group 2
Nicotine (electronic cigarette)
OTHER

Eligibility

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Age 21 (inclusive) years of age or greater
You have smoked cigarettes in the past 6 months. show original
Exhaled CO ≥ 6 ppm at baseline
You have a household income of less than $25,000 per year. show original
You are willing to substitute combustible cigarettes for EC or NPs. show original
Ability to read and write in English
Own a telephone (landline or cellphone)
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: through study completion, an average of 6 months
Screening: ~3 weeks
Treatment: Varies
Reporting: through study completion, an average of 6 months
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: through study completion, an average of 6 months.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Nicotine (electronic cigarette) will improve 3 primary outcomes and 5 secondary outcomes in patients with Smoking, Cigarette. Measurement will happen over the course of Assessed at baseline and week 8..

Change in cigarette dependence from baseline to week 8
ASSESSED AT BASELINE AND WEEK 8.
Change in cigarette dependence within group and between groups. Assessed using the Strong et al measure adapted from the Population Assessment of Tobacco and Health survey
ASSESSED AT BASELINE AND WEEK 8.
Change in 8-isoprostane from baseline to week 8
ASSESSED AT BASELINE AND WEEK 8.
8-isoprostane assessed via urine and compared within group and between groups
ASSESSED AT BASELINE AND WEEK 8.
Change in cotinine from baseline to week 8
ASSESSED AT BASELINE AND WEEK 8.
Creatinine-adjusted cotinine assessed via urine compared within group and between groups.
ASSESSED AT BASELINE AND WEEK 8.
Change in cigarettes per day from baseline to week 8
ASSESSED AT BASELINE AND WEEK 8.
Within and between group difference in past week average cigarettes per day assessed using timeline follow-back (TLFB)
ASSESSED AT BASELINE AND WEEK 8.
Change in NNAL from baseline to week 8
ASSESSED AT BASELINE AND WEEK 8.
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a ratio of NNAL to creatinine-adjusted cotinine assessed via urine and compared within group and between groups.
ASSESSED AT BASELINE AND WEEK 8.
Change in Carbon monoxide from baseline to week 8
ASSESSED AT BASELINE AND WEEK 8.
Exhaled carbon monoxide assessed via Smokerlyzer and compared within group and between groups.
ASSESSED AT BASELINE AND WEEK 8.
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Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get smoking, cigarette a year in the United States?

Approximately 1.2 million smokers in the United States will die from smoking-related causes. More effort is required to reduce smoking in the public and in physicians.

Anonymous Patient Answer

What is smoking, cigarette?

Tobacco use, in all its varied forms, from the inhalation of the smoke from a cigarette or pipeto smoking an open-ended pipe or cigar, is one of the greatest known causes of preventable death in the United States. It is estimated that the number of cigarette smokers exceeds 120 million individuals in the United States at any given time. Tobacco consumption has been identified by the Surgeon General of the United States as the number 1 preventable risk factor for disease and death in the country.

Anonymous Patient Answer

What causes smoking, cigarette?

There is evidence that tobacco use may play a significant role in starting and developing a desire to smoke cigarettes as well as in maintaining the habit. Smoking may be most strongly linked to lower levels of academic attainment.

Anonymous Patient Answer

What are the signs of smoking, cigarette?

Early signs of smoking include the absence of a parent to prevent them from having access to cigarettes, the presence of a parent who is not a smoker and the inability of the child to resist their mother's requests about smoking. In later life, signs of smoking include the early onset of smoking with other family members who are not smokers, early cigarette packs in school or college, reluctance to quit smoking, smoking in all the rooms without parental supervision, constant smoking at work and smoking with friends outside of work.

Anonymous Patient Answer

Can smoking, cigarette be cured?

The treatment of patients with lung cancer is difficult, but it is possible to improve the prognosis of those with smoking-related carcinoma. Results from a recent paper demonstrated that smoking can be effectively treated by combining treatment strategies and smoking cessation programs, which are more difficult when treating patients with brain or liver cancer.

Anonymous Patient Answer

What are common treatments for smoking, cigarette?

More is found to be common in the literature, but clinicians must be aware of their effects and the potential for harmful effects. The use of tobacco can lead to the development of [lung cancer](https://www.withpower.com/clinical-trials/lung-cancer), and smoking can damage the lungs, brain and body in many different ways. Smoking, smoke-free laws and bans on tobacco advertising and promotions are a few of the most useful programs for tobacco control. In addition, smoking and tobacco use increase the risk of developing cancer of the mouth, throat and larynx. In recent years, tobacco smoking has increased among patients with cancer, resulting in a decreased survival. Furthermore, the use of smoking in conjunction with radiation therapy has been reported.

Anonymous Patient Answer

Has nicotine (nicotine pouch) proven to be more effective than a placebo?

A 3-week trial using a nicotine patch with a regimen to manage symptoms of nicotine withdrawal found no difference in the proportion of patients who had a symptom score of less than two versus greater than or equal to two.

Anonymous Patient Answer

What are the latest developments in nicotine (nicotine pouch) for therapeutic use?

Currently, nicotine pouches in use for smoking cessation are available in patch form or spray form and are manufactured from a wide range of ingredients. As the research and testing continue, more innovative and convenient treatments will be available for smoking cessation and other non-nicotine diseases. Please see related article: Pouch for Smokeless Use.

Anonymous Patient Answer

What is the average age someone gets smoking, cigarette?

It is important to understand the average age of obtaining cigarette. There is a very wide variability of cigarette smoking behavior and the overall average age smoked during a lifetime. It is also important to understand the factors related to tobacco dependency and addiction. It is known that at the early age of 20–25 years, a larger proportion of boys and men started smoking. More than one third of Polish adults are currently smoking. This is the biggest rate in the European Union. It seems that Poland is the European Union region with the highest lifetime prevalence of smokers. The average age of smoking is 18 years and is decreasing. However, some countries are facing a problem with growing smoking incidence rate among youth.

Anonymous Patient Answer

Does smoking, cigarette run in families?

Smoking families tend to smoke more than non-smoking families. This suggests both genetic and environmental influence. The fact that smoking families are more likely to smoke and smoke more may be a result of both genetic and environmental influence. Both genes can be linked to smoking.

Anonymous Patient Answer

What are the common side effects of nicotine (nicotine pouch)?

Nicotine is very addictive and may adversely affect the ability to maintain a healthy weight; therefore, people who start use nicotine are advised to minimize their usage and avoid heavy smoking whenever possible, including a cigarette or nicotine cigarette. The common side effects of nicotine (nicotine pouch) include headache and chest discomfort. It is recommended to take nicotine pouches after quitting smoking to avoid nicotine withdrawal symptoms. Nicotine comes in various pouches such as 'Loctal', 'Chill', and 'Pouch Twist'. Also, 'Pouch Twist' is a nicotine patch with a tobacco flavor. People can change nicotine pouches according to their needs.

Anonymous Patient Answer

How does nicotine (nicotine pouch) work?

Pouch usage may inhibit the use of nicotine in oral forms. Further studies are needed to compare the effectiveness of oral vs. nasal/liquidal forms of nicotine.

Anonymous Patient Answer
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