Habit Reversal Training for Tourette Syndrome

Recruiting · < 18 · All Sexes · Baltimore, MD

This study is evaluating whether a specific type of learning may be helpful for individuals with Tourette syndrome.

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About the trial for Tourette Syndrome

Eligible Conditions
Syndrome · Tourette Syndrome in Children · Tourette Syndrome in Adolescence · Tourette Syndrome · Habit Reversal Training · Tics

Treatment Groups

This trial involves 2 different treatments. Habit Reversal Training is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Habit Reversal Training
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

About The Treatment

First Studied
Drug Approval Stage
How many patients have taken this drug
Habit Reversal Training


This trial is for patients born any sex aged 18 and younger. There are 5 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
They have a moderate tic severity or greater, as evidenced by a YGTSS Total Tic Score greater than 13 (>9 for youth with motor or vocal tics only). show original
They have not received more than 4 previous sessions of HRT. show original
speak English fluently. show original
People who are not taking medication or who are on a stable dose of psychiatric medication for 8 weeks prior to enrollment are eligible to participate in this study. show original
age 8-17 years (inclusive)
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Odds of Eligibility
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Within 1 week after completion of HRT
Screening: ~3 weeks
Treatment: Varies
Reporting: Within 1 week after completion of HRT
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Within 1 week after completion of HRT.
View detailed reporting requirements
Trial Expert
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- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Habit Reversal Training will improve 1 primary outcome and 1 secondary outcome in patients with Tourette Syndrome. Measurement will happen over the course of Within 1 week after completion of HRT.

Tic severity as assessed by the Hopkins Motor and Vocal Tic Scale (HM/VTS)
Patient will nominate up to five motor and five vocal tics they deem bothersome on the HM/VTS. Each bothersome tic is then rated by a clinician on the composite two (vocal and motor) 5-point HM/VTS scale ranging from none (0) to severe (4) for the motor as well as vocal tics. The individual tic scores are summed (minimum of 0 and maximum of 40) and averaged together to create an average tic severity score.
Tic severity as assessed by the Yale Global Tic Severity Scale-Revised (YGTSS)
The YGTSS is a clinician-rated semi-structured interview that measures tic symptom severity over the previous week. It consists of 10-items that assess different dimensions of tic severity for motor and vocal tics, which are rated on a 0-5 scale. The YGTSS produces a Total Tic Score (range: 0-50), with higher ratings indicating greater tic severity. The YGTSS has demonstrated treatment sensitivity to pharmacotherapy and behavioral interventions.

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does habit reversal training usually treat?

There may be a causal relationship; specifically, a habit arising from a tic may, with treatment, resolve, leaving the individual free from tics. A habitually ticked individual must first work with a habit trainer to identify which tic they have, and it may be difficult to identify a habit which can be removed by habit reversal techniques.

Anonymous Patient Answer

How many people get tourette syndrome a year in the United States?

It is estimated that 1.6 million Americans were diagnosed with Tourette syndrome. Although the majority of cases (62-69%) were reported to be in males, these estimates should be interpreted with caution, as several factors such as diagnostic criteria and study base make it hard to draw firm conclusions. However, given the strong prevalence of tic disorders, and the burden imposed by Tourette syndrome on both sufferers and their families, the current estimates are very important.

Anonymous Patient Answer

What are the signs of tourette syndrome?

Physical signs of tics include tremor, rapid movement of the arms and hands and muscle stiffness. Individuals may also have involuntary movements of the neck. There are also several social and cognitive signs. The disorder may affect social or family relationships, adversely impacting on quality of life and mental health. \n

Anonymous Patient Answer

What causes tourette syndrome?

Tourette syndrome is associated with abnormal dopaminergic neurotransmission, but the precise underlying mechanism and the molecular genetic basis, which are unknown, are yet to be elucidated. Current treatment options aim to improve the symptoms but do not address the etiology of the disorder.

Anonymous Patient Answer

Can tourette syndrome be cured?

In order to be classified as cured, the tic would have to be under control for at least 6 months. Tourette syndrome cannot be cured.

Anonymous Patient Answer

What is tourette syndrome?

With the increasing use of medical school admission criteria, the identification of TS is now under-recognized. Most patients experience a history of anxiety and obsessive compulsions that develop in childhood and persist to adulthood. It was found that patients with TS experience a significantly higher rate of tics and obsessive-compulsive symptoms on admission to the medical school compared to matched controls. A lower rate of medical school admission and a delayed academic progress are common features among patients with TS once admitted.

Anonymous Patient Answer

What are common treatments for tourette syndrome?

The most effective treatments for TS include behavior modifications combined with clozapine and fluoxetine, clozapine alone, fluoxetine alone, and combined treatments of clozapine and fluoxetine. Patients with comorbid disorders should be treated carefully, with some medication adjustments. Those with persistent tics and those with comorbid psychiatric problems such as depression, schizophrenia, anxiety, or attention deficits may require admission for behavioral treatment. There is no one-size fix for treatment when managing TS.

Anonymous Patient Answer

How serious can tourette syndrome be?

While tourette syndrome is not fatal and it is usually slowly debilitating, it is possible to cause severe damage to one's life and health. Tourette syndrome can affect family relationships, school, social relationships, and work. A major concern with Tourette syndrome is its effect on the quality of life of the person diagnosed. A person with Tourette syndrome will live with an impaired ability to function in the workplace, maintain relationships, pursue hobbies, deal with family and social demands, and make normal daily life easier. Tourette syndrome is often overlooked in the media when addressing the issue of Tourette. Tourette is misunderstood by many as an embarrassing, embarrassing thing. It is usually treated by different specialists.

Anonymous Patient Answer

What is the primary cause of tourette syndrome?

The primary cause of Tourette syndrome is unknown. The common view among tic clinicians is that TS is a disorder where genetic, environmental, neuropsychiatric and neurovisceral factors play a significant role. However, while it has been suggested that Tourette syndrome is a genetic disorder that is often passed from parents to children, only a small proportion of Tourette syndrome families have a history of Tourette syndrome or tic phenotypes in first-degree relatives. Most children with Tourette syndrome (particularly male children) have a family history of tics or tic phenotype. This phenomenon suggests that the condition may be triggered by environmental and/or neuropsychiatric factors.

Anonymous Patient Answer

Have there been any new discoveries for treating tourette syndrome?

It is difficult to recommend any new treatments or medications with evidence to support their efficacy. The majority of individuals in clinical trials had to withdraw from studies early for lack of response to study treatment. In a recent study, findings of clinical trials do not allow prediction of the results in clinical practice or the potential efficacy of therapies in clinical practice.

Anonymous Patient Answer

Is habit reversal training typically used in combination with any other treatments?

This pilot data suggests that the habit reversal component of the program was not a good addition to existing treatment, and the additional cost was high. Therefore, if the benefits of habit reversal training are not validated with larger studies, this component should be removed from future versions of the program. Further work is required to determine the best way to add habit reversal training to existing clinical paradigms for treating obsessive compulsive behaviors.

Anonymous Patient Answer

What is habit reversal training?

HRT can be used after an acute tic episode with a small to moderate effect on symptoms. In patients presenting for chronic tic episodes, HRT cannot replace traditional treatment because of the long-term benefit seen with behavioral therapy. HRT also has no effect in the absence of tics.

Anonymous Patient Answer
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