← Back to Search

Bright Light + Exercise + Melatonin for Jet Lag

N/A
Waitlist Available
Led By Shawn Youngstedt, PhD
Research Sponsored by University of Arizona
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6.5 days
Awards & highlights

Summary

This trial will compare the efficacy of three different treatments for circadian adjustment to a laboratory protocol simulating westward air travel.

Eligible Conditions
  • Jet Lag

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6.5 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6.5 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change (shift) in the acrophase of the rhythm of the median reaction time
Change (shift) in the acrophase of urinary 6-sulphatoxymelatonin (aMT6s) excretion
Change in sleep duration
Secondary outcome measures
Change (shift) in the acrophase of the Stanford Sleepiness Scale
Change (shift) in the acrophase of the Total Mood Disturbance composite scale of on the Profile of Mood States questionnaire
Change (shift) in the acrophase of the Wingate Anaerobic Performance Test
+1 more

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Bright Light AloneExperimental Treatment1 Intervention
Bright light administered with Re-Timer glasses for 1 hour on 3 consecutive days. Following the 8 hour delay of the light/dark and sleep/wake cycle in the laboratory, the light will be administered, on average at 5:30-6:30 pm, 7:00-8:00 pm, and 9:30-10:30 pm, respectively on these three days.
Group II: Bright Light + Exercise + MelatoninExperimental Treatment1 Intervention
Bright light will be administered with Re-Timer glasses for 1 hour on 3 consecutive days. Following the 8 hour delay of the light/dark and sleep/wake cycle in the laboratory, the light will be administered, on average at 5:30-6:30 pm, 7:00-8:00 pm, and 9:30-10:30 pm, respectively on these three days. Exercise (1 hour at 65-75% heart rate reserve) will be administered on 3 consecutive, at 1:30-2:30 pm, 4:00-5:00 pm, and 6:30-7:30 pm on these days. Melatonin (0.5 mg) will be administered at 6 am, 8:30 am, and 11:00, on the 3 days.
Group III: Placebo ControlPlacebo Group1 Intervention
Dim red light will be administered with Re-Timer glasses for 1 hour on 3 consecutive days. Following the 8 hour delay of the light/dark and sleep/wake cycle in the laboratory, the light will be administered, on average at 5:30-6:30 pm, 7:00-8:00 pm, and 9:30-10:30 pm, respectively on these three days. Placebo tablets (0.5 mg) will be administered at 6 am, 8:30 am, and 11:00, on the 3 days.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bright Light
2013
N/A
~120

Find a Location

Who is running the clinical trial?

University of ArizonaLead Sponsor
518 Previous Clinical Trials
148,673 Total Patients Enrolled
University of California, San DiegoOTHER
1,135 Previous Clinical Trials
1,551,208 Total Patients Enrolled
Shawn Youngstedt, PhDPrincipal InvestigatorUniv Arizona
~9 spots leftby Jul 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top