This trial is evaluating whether Overnight polysomnography examinations will improve 2 primary outcomes in patients with Schizophrenia. Measurement will happen over the course of Day 16, immediate upon wakening.
This trial requires 40 total participants across 2 different treatment groups
This trial involves 2 different treatments. Overnight Polysomnography Examinations is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
"The main treatments for schizophrenia are medication and hospital care, although family therapy is sometimes used following the breakdown of social support. The severity of schizophrenia is related to treatment choice, the need (or motivation) for treatment and the social support available." - Anonymous Online Contributor
"Schizophrenia is a chronic psychotic disorder in which psychotic symptoms are generally present for a long period of time, are relatively stable, and are not adequately relieved by medication. Patients often exhibit cognitive and affective dysfunction. Schizophrenic patients are categorized in several different ways, including by age when onset, course, and disability.\n" - Anonymous Online Contributor
"Schizophrenia can result in symptoms such as loss of interest in art, low self-esteem, poor concentration, social withdrawal, low energy, feeling that the world is hostile, poor thinking and sensory distortions and hallucinations. Schizophrenia sometimes occurs before the first episode of psychosis and can then be hard to differentiate from other psychiatric disorders.\n" - Anonymous Online Contributor
"The number of Americans diagnosed with schizophrenia will increase over the time span. It takes 15.6 percent more schizophrenic individuals to become diagnosed over an 8-year span than over a 5-year span." - Anonymous Online Contributor
"There is a strong effect of genetics and a much lower effect of pollution. The environment may be an important factor in childhood, but the mechanisms are probably not clearly understood. Most children, if not all, are born with schizophrenia, whereas in the general population only 1% are. In children, the age of onset is a factor. This suggests that schizophrenia is a developmental disorder." - Anonymous Online Contributor
"Given that people with schizophrenia do not typically die of natural causes, these views should not be taken as evidence that schizophrenia cannot be cured. Moreover, many people in the public and healthcare sectors appear to value the views of those who believe that schizophrenia cannot be cured, and there appears to be little evidence for the views being held by the community at large." - Anonymous Online Contributor
"It seems that schizophrenic mothers are a good genetic model in addition to schizophrenic fathers. There is also an association between a male first-degree relative with the occurrence of psychotic episodes. This association is stronger than a family history of psychotic episodes." - Anonymous Online Contributor
"Overnight PSG evaluation can reveal changes of brain activity in sleep patterns and sleep stages during a day time session in patients who do not have obvious symptoms. We think that an overnight PSG can give more information to diagnose sleep disturbances in the patients and the usefulness of PSG evaluations in the clinical decisions." - Anonymous Online Contributor
"In the majority of cases overnight PSGs were well tolerated and provided important new insight into people's sleep architecture and their neurological state during the sleep period." - Anonymous Online Contributor
"In our patients, no changes were observed between the two test conditions (even though we used a rigorous methodology in an attempt to reduce the noise inherent to polysomnography) as well as between both conditions and controls. In some patients, but not in the entire group, periodic changes, usually of short duration, were observed between NREM sleep and wakefulness: this could be due to NREM sleep-related events that did not reach the criteria. A future study on a larger sample size, using a randomisation procedure, would help clarify this issue." - Anonymous Online Contributor
"Results from a recent paper support previous suggestions that objectively measured sleep quality can benefit psychological wellbeing in people with psychotic disorders. The small absolute gain in the GCSQ score (1%) observed with OPA does not translate to a reduction in quality of life, but the increased incidence of severe sleep disturbances may have a negative impact on quality of life. Future research into treatment of sleep disorders will be necessary to investigate whether OPA is suitable as a treatment for sleep-related disturbance in people suffering from psychosis, or whether it is appropriate in only some patients." - Anonymous Online Contributor
"The PSG has no role in diagnosing a patient unless sleep studies are ordered for other reasons. On the other hand, the PSG can aid in the management of the patient, in particular when the patient has more than a few episodes per week, or if sleep studies indicate the presence of the sleep variant atonia. The PSG cannot provide a diagnosis or be used to rule out other sleep disorders which might be more obvious and require less invasive testing because of their relatively specific presentation, such as obstructive sleep apneas and circadian rhythm sleep disorders." - Anonymous Online Contributor