Auditory Stimulation for Schizophrenia

Led By Dara Manoach, PhD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Male and female schizophrenia outpatients
Be between 18 and 65 years old
Must not have
Be younger than 18 years old
Be older than 65 years old
Screening 3 weeks
Treatment Varies
Follow Upplacebo and auditory stimulation naps will be approximately one week apart
Awards & highlights

Study Summary

This trial will test whether playing quiet sounds during sleep can normalize brain activity and improve memory in patients with schizophrenia.

Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below
The study is looking for male and female outpatients who have schizophrenia.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~placebo and auditory stimulation naps will be approximately one week apart
This trial's timeline: 3 weeks for screening, Varies for treatment, and placebo and auditory stimulation naps will be approximately one week apart for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Differences in slow-oscillation spindle coupling
Secondary outcome measures
Differences in sleep spindles
Differences in sleep-dependent consolidation of motor procedural memory
Differences in slow oscillations

Trial Design

2Treatment groups
Experimental Treatment
Group I: SchizophreniaExperimental Treatment2 Interventions
Adult outpatients with a diagnosis of schizophrenia.
Group II: Healthy ControlsExperimental Treatment2 Interventions
Adult participants screened to exclude a personal history of mental illness, family history of schizophrenia spectrum disorder, and psychoactive medication use.

Find a site

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,832 Previous Clinical Trials
13,567,211 Total Patients Enrolled
44 Trials studying Schizophrenia
9,134 Patients Enrolled for Schizophrenia
Dara Manoach, PhDPrincipal Investigator
Massachusetts General Hospital
2 Previous Clinical Trials
80 Total Patients Enrolled

Media Library

Auditory Stimulation Clinical Trial Eligibility Overview. Trial Name: NCT04783571 — N/A
Schizophrenia Research Study Groups: Schizophrenia, Healthy Controls
Schizophrenia Clinical Trial 2023: Auditory Stimulation Highlights & Side Effects. Trial Name: NCT04783571 — N/A
Auditory Stimulation 2023 Treatment Timeline for Medical Study. Trial Name: NCT04783571 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are any new participants being taken on for this clinical research program?

"As indicated on the, this medical investigation is actively searching for participants. It was originally posted to the website in April of 2020 and last updated August 2021."

Answered by AI

Does this medical trial accept patients aged fifty and older?

"Patients 18 years of age or older but not yet 50 will be considered for enrollment in this research."

Answered by AI

Does my profile qualify me to partake in this trial?

"This clinical trial seeks to enlist approximately 70 participants with a diagnosis of schizophrenia and an age range between 18-50 years old."

Answered by AI

To what extent is the trial population being monitored?

"Affirmative, the information available on verifies that this medical trial is presently searching for eligible candidates. It was initially published on April 13th of 2020 and most recently updated on August 16 2021. 70 subjects are needed at a single site to participate in the study."

Answered by AI
~13 spots leftby Jul 2024