Sleep Management for Sleep Deprivation

Recruiting at 1 trial location

Overseen By Robert Stickgold, PhD

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Beth Israel Deaconess Medical Center

Must not be taking: Sleeping pills, Antidepressants

Disqualifiers: Sleep disturbances, Mental illness, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

100 Participants Needed

Trial Summary

What is the purpose of this trial?

To further understand the impact of acute sleep deprivation and recovery sleep on the processing of emotional information the investigators will address and attempt to answer three questions, (i) how both undisturbed sleep and sleep deprivation affect the processing and retrieval of emotional information, (ii) what neural and psychophysiological mechanisms are associated with these behavioral effects, and (iii) to explore the ability of recovery sleep to reverse the effects of sleep deprivation. Together, these studies will provide a greater breadth and depth of knowledge concerning sleep's role in emotion processing and regulation. Given the growing societal tendency to view sleep as unproductive-foregoing it to lengthen work days and increase social opportunities- such knowledge would be of practical importance for understanding the role of sleep in healthy emotional functioning, particular for individuals experiencing periods of increased stress and emotional distress (e.g., new parents, hospital staff, or combat troops).

Will I have to stop taking my current medications?

Yes, you will need to stop taking any drugs that could affect sleep or cognitive functioning, such as sleeping pills or antidepressants, to participate in this trial.

What data supports the effectiveness of the treatment for Sleep Management for Sleep Deprivation?

Research suggests that improving sleep quality through non-drug methods, like clustering care at night, can help patients recover better from sleep deprivation. Although studies on these interventions often have mixed results, they are recommended as a first-choice treatment to enhance sleep and overall recovery. ^{1 2 3 4 5}

Is sleep management for sleep deprivation generally safe for humans?

Research shows that sleep deprivation can lead to health issues like diabetes and heart disease, but recovery sleep (extra sleep after being sleep-deprived) is generally safe and helps improve memory and reduce errors, especially in shift workers. ^{1 6 7 8 9}

How is the treatment of sleep deprivation unique compared to other treatments?

The treatment of sleep deprivation, also known as sleep loss or insufficient sleep, is unique because it involves therapeutic sleep deprivation or induced-wakefulness therapy, which has been shown to have antidepressive effects. Unlike other treatments that focus on improving sleep quality or duration, this approach uses controlled sleep deprivation as a therapeutic tool, particularly for depressive disorders. ^{4 10 11 12 13}

Research Team

Tony Cunningham, PhD

Principal Investigator

Beth Israel Deaconess Medical Center

Eligibility Criteria

This trial is for individuals who can follow the study's rules and are willing to avoid alcohol and recreational drugs during the study. They must have normal vision (with or without correction) and be right-handed. People with sleep issues, mental illness, neurological disorders, or those taking medication affecting sleep or cognition cannot participate.

Inclusion Criteria

Willing and able to meet inclusion criteria for fMRI scanning

Willing to refrain from alcohol and recreational drugs for the duration of the protocol

Normal or corrected to normal vision is required

Exclusion Criteria

You have trouble sleeping and have reported it yourself.

You are left-handed or can use both hands equally well.

You have a history of mental illness or problems with your brain or nerves.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Sleep Deprivation

Participants undergo sleep deprivation before participating in training and testing sessions

1 day

1 visit (in-person)

Daytime Nap

Participants are given a 2-hour nap opportunity to quantify its restorative effects

2 hours

1 visit (in-person)

Overnight Sleep

Participants are permitted a night of polysomnograph-recorded sleep before participating in training and testing sessions

1 night

1 visit (in-person)

Follow-up

Participants are monitored for changes in emotional memory and affective reactivity after interventions

1-2 days

Treatment Details

Interventions

• Daytime nap
• Sleep Deprivation

Trial Overview The study examines how lack of sleep and recovery sleep affect emotional memory and mood reactions. It will look at how a good night's rest versus being awake all night influences emotions, what brain activities are linked to these effects, and if a nap can help reverse any negative impacts of missed sleep.

Participant Groups

Group I: Daytime Nap Experimental Treatment 2 Interventions

Subjects are trained and then retested after a daytime nap

Group II: Sleep deprivation Active Control 1 Intervention

Subjects sleep deprived before participating in training and testing sessions the next day

Group III: Overnight sleep Active Control 1 Intervention

Subjects are permitted a night of polysomnograph-recorded sleep before participating in training and testing sessions the next day

Who Is Running the Clinical Trial?

Beth Israel Deaconess Medical Center

Lead Sponsor

Trials

872

Recruited

12,930,000+

Boston College

Collaborator

Trials

40

Recruited

49,300+

Findings from Research

Sleep quality in ICU and acute ward settings is significantly affected by environmental factors like noise and light, as well as illness-related issues such as pain and anxiety.

Effective sleep-promoting strategies include both pharmacological aids and non-pharmacological methods, such as reducing noise and using earplugs or eye masks, highlighting the need for healthcare professionals to implement behavioral changes to enhance patient sleep.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Interventions to improve inpatients' sleep quality in intensive care units and acute wards: a literature review. Aparício, C., Panin, F.[2022]

In a study with 20 healthy adults, recovery from one night of total sleep deprivation was significantly better with 9 hours of sleep compared to 6 hours, highlighting the importance of total sleep time (TST) for recovery.

Participants who had only 6 hours of recovery sleep showed persistent deficits in waking functions, with response times and alertness remaining below baseline levels throughout the recovery period, indicating that restricted sleep opportunities hinder recovery.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The characteristics of recovery sleep when recovery opportunity is restricted. Jay, SM., Lamond, N., Ferguson, SA., et al.[2019]

In a study of 50 critically ill patients across 4 intensive care units, it was found that patients experienced an average of 42.6 care interactions per night, significantly disrupting their sleep, with only 9 nights allowing for 2 to 3 hours of uninterrupted sleep.

The study highlighted that most care activities, including routine baths, occurred during nighttime hours, suggesting a need for targeted interventions to reduce nighttime disruptions and promote better sleep for critically ill patients.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Nocturnal care interactions with patients in critical care units. Tamburri, LM., DiBrienza, R., Zozula, R., et al.[2022]

Sleep deprivation is a major issue for patients in critical care units, significantly affected by factors like noise, light, discomfort, and frequent medical interventions.

To improve patient sleep quality, it is essential to educate healthcare providers about sleep stages and integrate sleep management into care plans, including evaluating the impact of medications on sleep.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Sleep deprivation in critical care units. Honkus, VL.[2019]

In a study involving 374 hospitalized patients, nonpharmacologic interventions such as earplugs, eye masks, and aromatherapy led to a significant increase in total sleep time by 40 minutes compared to usual care, with patients in the intervention group averaging 6 hours and 45 minutes of sleep.

The postponement of morning vital sign checks and medication rounds from night to day significantly reduced sleep disturbances, suggesting that simple changes in hospital routines can enhance patient sleep quality.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Evaluation of Nonpharmacologic Interventions and Sleep Outcomes in Hospitalized Medical and Surgical Patients: A Nonrandomized Controlled Trial. van den Ende, ES., Merten, H., Van der Roest, L., et al.[2022]

Sleep deprivation is linked to serious health issues such as increased risk of all-cause mortality, diabetes, and cardiovascular disease, highlighting the importance of addressing sleep disorders for public health.

Treating obstructive sleep apnea is a cost-effective healthcare intervention, providing significant quality-adjusted life years gained compared to other medical therapies, making it a valuable focus for improving patient outcomes.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The public health and safety consequences of sleep disorders. Sigurdson, K., Ayas, NT.[2007]

Insufficient sleep is a major public health issue influenced by various factors such as sleep disorders, medical conditions, and lifestyle choices, leading to significant health consequences.

The article emphasizes the need for precision medicine to better understand sleep insufficiency and develop personalized strategies to improve sleep quality and patient outcomes.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Precision Medicine for Sleep Loss and Fatigue Management. Pichard, LE., Simonelli, G., Schwartz, L., et al.[2019]

Chronic sleep restriction (5 hours of sleep for 5 nights) significantly impaired spatial working memory performance in healthy participants, even after a recovery night of sleep, highlighting the lasting effects of sleep deprivation on cognitive function.

Acute sleep deprivation (38 hours without sleep) further exacerbated impairments in spatial working memory for those with prior chronic sleep loss, indicating that individuals with sleep deficits are more vulnerable to cognitive decline during periods of acute sleep loss.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Adverse interaction effects of chronic and acute sleep deficits on spatial working memory but not on verbal working memory or declarative memory. Hennecke, E., Lange, D., Steenbergen, F., et al.[2021]

Regulations on duty hours and rest periods are crucial for maintaining safety and accreditation in medical settings, as non-compliance can lead to serious consequences.

Understanding the science of sleep is becoming increasingly important in the medical field, highlighting the need for proper rest to ensure optimal performance and patient care.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

New graduate standards limit residents' hours. [2007]

Therapeutic sleep deprivation has been shown to have antidepressant effects, supported by numerous studies since its introduction in 1971, making it a potential treatment option for depressive disorders.

Partial sleep deprivation late at night is as effective as total sleep deprivation, offering a simpler and more practical method for inducing wakefulness in patients.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Sleep deprivation therapy. Kuhs, H., Tölle, R.[2019]

Sleep fragmentation and deprivation lead to increased sleepiness, decreased performance on memory and reaction tasks, and worsened mood, with the severity of these symptoms linked more to the amount of sleep lost than the type of disturbance.

Both conditions can worsen sleep apnea, highlighting the need for clinicians to identify and treat Insufficient Sleep Syndrome, especially as these issues are common in today's society.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Clinical effects of sleep fragmentation versus sleep deprivation. Bonnet, MH., Arand, DL.[2022]

Sleep deprivation has serious effects on health and performance, making it essential for individuals to prioritize getting enough quality sleep based on their personal needs.

For those unable to achieve adequate sleep due to medical conditions or work demands, wake-promoting medications like caffeine and modafinil can help manage excessive daytime sleepiness.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Countermeasures for sleep loss and deprivation. Kushida, CA.[2020]

Sleep deficiency is a widespread issue in modern society, influenced by various factors such as occupation, social demands, and health conditions, affecting both physical and mental health.

The consequences of inadequate sleep can significantly impact cognitive function, mood, and overall health, including diabetes and cardiovascular health, highlighting the importance of addressing sleep quality and duration.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Sleep Deficiency: Epidemiology and Effects. Gohari, A., Baumann, B., Jen, R., et al.[2022]

References

1. England pubmed.ncbi.nlm.nih.gov

Interventions to improve inpatients' sleep quality in intensive care units and acute wards: a literature review. [2022]

2. United States pubmed.ncbi.nlm.nih.gov

The characteristics of recovery sleep when recovery opportunity is restricted. [2019]

3. United States pubmed.ncbi.nlm.nih.gov

Nocturnal care interactions with patients in critical care units. [2022]

4. United States pubmed.ncbi.nlm.nih.gov

Sleep deprivation in critical care units. [2019]

5. United States pubmed.ncbi.nlm.nih.gov

Evaluation of Nonpharmacologic Interventions and Sleep Outcomes in Hospitalized Medical and Surgical Patients: A Nonrandomized Controlled Trial. [2022]

6. Canada pubmed.ncbi.nlm.nih.gov

The public health and safety consequences of sleep disorders. [2007]

7. United States pubmed.ncbi.nlm.nih.gov

Precision Medicine for Sleep Loss and Fatigue Management. [2019]

8. England pubmed.ncbi.nlm.nih.gov

Adverse interaction effects of chronic and acute sleep deficits on spatial working memory but not on verbal working memory or declarative memory. [2021]

9. United States pubmed.ncbi.nlm.nih.gov

New graduate standards limit residents' hours. [2007]

10. United States pubmed.ncbi.nlm.nih.gov

Sleep deprivation therapy. [2019]

11. England pubmed.ncbi.nlm.nih.gov

Clinical effects of sleep fragmentation versus sleep deprivation. [2022]

12. United States pubmed.ncbi.nlm.nih.gov

Countermeasures for sleep loss and deprivation. [2020]

13. United States pubmed.ncbi.nlm.nih.gov

Sleep Deficiency: Epidemiology and Effects. [2022]