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Non-nutritive Sweetener
Non-nutritive Sweeteners for Metabolic Syndrome
N/A
Waitlist Available
Led By Marie-Claude Vohl
Research Sponsored by Laval University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 18-24 months
Awards & highlights
Study Summary
This trial will test the effects of two types of non-nutritive sweeteners, stevia and aspartame, on metabolic health and the gut microbiome.
Who is the study for?
This trial is for men and women who are generally healthy and regularly consume soft drinks, ranging from 4 cans a week up to 4 cans a day. It's not suitable for those with recent surgeries, allergies to drink ingredients, recent antibiotic use, heavy alcohol consumption, or changes in medication or weight.Check my eligibility
What is being tested?
The study tests the effects of daily consumption of three types of beverages over 10 weeks: regular sugary soft drinks, diet soft drinks with artificial sweeteners like aspartame, and stevia-sweetened soft drinks on metabolic health and gut microbiome.See study design
What are the potential side effects?
Potential side effects may include changes in metabolism or gut health due to the different sweeteners used. These could affect blood sugar levels, digestion processes or cause other metabolic disturbances.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 18-24 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~18-24 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Insulin
Secondary outcome measures
Changes in gut microbiota composition of SSB consumers following regular, diet or stevia-sweetened beverages intakes for 10 weeks.
Changes in intestinal homeostasis of SSB consumers following regular, diet or stevia-sweetened beverages intakes for 10 weeks.
Other outcome measures
Changes in key molecular signaling pathways and metabolic regulatory networks identified through transcriptomics and metabolomics of SSB consumers following regular, diet or stevia-sweetened beverages intakes for 10 weeks.
Trial Design
3Treatment groups
Experimental Treatment
Active Control
Group I: Stevia beveragesExperimental Treatment1 Intervention
Soft drinks sweetened with natural non-nutritive sweeteners (i.e. steviol glycosides)
Group II: Diet beveragesExperimental Treatment1 Intervention
Soft drinks sweetened with artificial non-nutritive sweeteners (i.e. aspartame, acesulfame-K)
Group III: Regular beveragesActive Control1 Intervention
Sugar sweetened soft drinks
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Who is running the clinical trial?
Laval UniversityLead Sponsor
417 Previous Clinical Trials
172,231 Total Patients Enrolled
26 Trials studying Metabolic Syndrome
1,994 Patients Enrolled for Metabolic Syndrome
Marie-Claude VohlPrincipal InvestigatorLaval University
3 Previous Clinical Trials
141 Total Patients Enrolled
2 Trials studying Metabolic Syndrome
118 Patients Enrolled for Metabolic Syndrome
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have not had surgery in the last 3 months and do not plan to during the study.You are allergic or intolerant to any ingredients in soft drinks.I have a condition like high blood pressure, diabetes, or high cholesterol.I have not taken antibiotics in the last 3 months.I have not changed my use of natural health products in the last 3 months.Your weight has changed by more than 5% in the last 3 months.People who drink between 4 cans of soft drinks per week to 4 cans per day.I am in good health.You drink more than 2 alcoholic drinks per day.I regularly take medication that could affect the study.My medication type or dose has not changed in the past year.You drink more than 4 cans of soda every day.
Research Study Groups:
This trial has the following groups:- Group 1: Regular beverages
- Group 2: Diet beverages
- Group 3: Stevia beverages
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is enrollment for this experiment open to the public right now?
"As per the details hosted on clinicaltrials.gov, this experiment is not currently seeking participants; it was originally posted in October 2017 and last updated September 2022. However, there are 152 other trials actively recruiting at the moment."
Answered by AI
Who is eligible to enroll in this experiment?
"This clinical research is seeking 41 individuals aged 18-75 who have metabolic syndrome. To qualify, men and women must also present a picture of good health."
Answered by AI
Does this investigation accept participants of a minimum age of twenty or above?
"This clinical trial stipulates that participants must be between 18 and 75 years old. In addition, there are 11 studies for minors aged below 18, as well as 112 trials available to seniors over the age of 65."
Answered by AI
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