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High Flow Nasal Oxygen for Respiratory Support (HDWOBSS Trial)
N/A
Waitlist Available
Research Sponsored by Laval University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 10 minutes
Awards & highlights
HDWOBSS Trial Summary
This trial will study the work of breathing of healthy subjects under different conditions while using high flow nasal cannulas. 10 subjects will be included and will experience 5 different treatment periods with different flow settings.
Who is the study for?
This trial is for healthy individuals who can give informed consent. It's not suitable for those with a history of digestive, cardiovascular or respiratory diseases, pregnant or breastfeeding women, people in other studies (except co-enrolment), or anyone with recent ear, nose, throat surgery or conditions that could affect the study.Check my eligibility
What is being tested?
The study is testing how different flow settings from high flow nasal cannulas affect breathing effort compared to conventional nasal prongs. Ten participants will experience five treatment periods with varying flows in a crossover design—each person tries all treatments at different times.See study design
What are the potential side effects?
Since this trial involves healthy subjects and non-invasive interventions like high flow nasal cannulas and conventional prongs, significant side effects are unlikely but may include discomfort in the nose or throat due to airflow.
HDWOBSS Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 10 minutes
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10 minutes
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Work of breathing
Secondary outcome measures
Blood gases
Comfort of breathing
Dyspnea
+6 moreHDWOBSS Trial Design
5Treatment groups
Experimental Treatment
Active Control
Group I: High flow nasal cannulas 60 L/minExperimental Treatment1 Intervention
Subjects will be breathing with high flow nasal cannulas delivering 60 L/min with an inspired fraction of oxygen of 0.21.
Group II: High flow nasal cannulas 40 L/minExperimental Treatment1 Intervention
Subjects will be breathing with high flow nasal cannulas delivering 40 L/min with an inspired fraction of oxygen of 0.21.
Group III: High flow nasal cannulas 20 L/minExperimental Treatment1 Intervention
Subjects will be breathing with high flow nasal cannulas delivering 20 L/min with an inspired fraction of oxygen of 0.21.
Group IV: Conventional flow via nasal prongsExperimental Treatment1 Intervention
Subjects will be breathing with nasal prongs delivering 5 L/min of air (inspired fraction of oxygen: 0.21)
Group V: No flowActive Control1 Intervention
Subjects will be spontaneously breathing in room air with no flow.
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Who is running the clinical trial?
Laval UniversityLead Sponsor
419 Previous Clinical Trials
172,286 Total Patients Enrolled
5 Trials studying Respiratory Failure
606 Patients Enrolled for Respiratory Failure
François Lellouche, MD, PhDStudy DirectorFondation IUCPQ
2 Previous Clinical Trials
46 Total Patients Enrolled
1 Trials studying Respiratory Failure
16 Patients Enrolled for Respiratory Failure
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Eligibility Criteria:
This trial includes the following eligibility criteria:- I have a heart or lung condition.I have a history of rheumatologic or neurologic disease that may affect study participation.I feel nauseous or have eaten in the last hour.I have had issues or procedures done on my ear, nose, or throat.I have had issues with bleeding or varices in my esophagus or stomach.People who are not sick.
Research Study Groups:
This trial has the following groups:- Group 1: Conventional flow via nasal prongs
- Group 2: High flow nasal cannulas 40 L/min
- Group 3: No flow
- Group 4: High flow nasal cannulas 60 L/min
- Group 5: High flow nasal cannulas 20 L/min
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are prospective participants able to join this trial at the present moment?
"The clinicaltrial.gov platform reports that this medical trial is not currently seeking participants, despite being initially posted on June 1st 2015 and revised July 10th 2015. Fortunately, there are 176 other studies actively recruiting at present."
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