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ilioinguinal/iliohypogastric nerve block for Postoperative Pain

N/A
Waitlist Available
Research Sponsored by Alberta Children's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Healthy children (ASA I and II) between the ages of 6 months and 4 years presenting for elective hernia repair who are scheduled for day stay only.
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 hours post-operatively
Awards & highlights

Study Summary

Surgical intervention to treat a inguinal hernia is a very common pediatric surgical procedure, often performed using an inguinal incision. Children who undergo hernia repair can suffer from a significant degree of discomfort postoperatively. The investigators are evaluating the effectiveness of an ultrasound guided caudal-epidural (CE) block to an US guided ilioinguinal/iliohypogastric (IIG/IHG) nerve block in achieving post operative analgesia following a hernia repair. It is hypothesized that US guided IIG/IHG nerve block leads to more effective pain control post-operatively while in hospital relative to an US guided CE block for inguinal hernia surgery.

Eligible Conditions
  • Postoperative Pain
  • Inguinal Hernia

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 hours post-operatively
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 hours post-operatively for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Secondary outcome measures
Pain
Total acetaminophen consumption
Total ibuprofen consumption

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: ilioinguinal/iliohypogastric nerve blockExperimental Treatment9 Interventions
All patients will receive acetaminophen (15mg/kg) within one hour of induction of anesthesia. Inhalation induction of anesthesia will be performed with sevoflurane in 100% O2. A single dose of up to 2-4 mg/kg of propofol and Remifentanil 0.5-1mcg/kg will be given prior insertion of a laryngeal mask airway or endotracheal tube. Anesthesia will be maintained with Propofol and Remifentanil (2.5mcg/ml) which will be started at 300 mcg/kg/min and titrated to effect. If necessary additional boluses of Propofol (1mg/kg) and/or Remifentanil (0.5-1mcg/kg) and/or Morphine 0.05mg/kg boluses IV will be administered. Ondansetron (0.1mg/kg) and Dexamethasone (0.15mg/kg) will be given as antiemetic prophylaxis for all patients. Ketorolac 0.3mg/kg will be given to each patient. The IIG/IHG group will receive a unilateral US guided IIG/IHG with 0.4mL/kg of ropivacaine 0.2% (max 12 mL).
Group II: Caudal-epidural nerve blockActive Control9 Interventions
All patients will receive acetaminophen (15mg/kg) within one hour of induction of anesthesia. Inhalation induction of anesthesia will be performed with sevoflurane in 100% O2. A single dose of up to 2-4 mg/kg of propofol and Remifentanil 0.5-1mcg/kg will be given prior insertion of a laryngeal mask airway or endotracheal tube. Anesthesia will be maintained with Propofol and Remifentanil (2.5mcg/ml) which will be started at 300 mcg/kg/min and titrated to effect. If necessary additional boluses of Propofol (1mg/kg) and/or Remifentanil (0.5-1mcg/kg) and/or Morphine 0.05mg/kg boluses IV will be administered. Ondansetron (0.1mg/kg) and Dexamethasone (0.15mg/kg) will be given as antiemetic prophylaxis for all patients. Ketorolac 0.3mg/kg will be given to each patient. The CE group will receive an US-confirmed CE nerve block with 0.8 mL/kg of 0.2% ropivacaine (maximum 15 mL).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Propofol
FDA approved
Dexamethasone
FDA approved
Ilioinguinal/iliohypogastric nerve block
2015
N/A
~90
Morphine
FDA approved
Ondansetron
FDA approved
Ketorolac
FDA approved
Acetaminophen
FDA approved
Sevoflurane
FDA approved
Remifentanil
FDA approved

Find a Location

Who is running the clinical trial?

Alberta Children's HospitalLead Sponsor
53 Previous Clinical Trials
39,939 Total Patients Enrolled
University of SaskatchewanOTHER
251 Previous Clinical Trials
154,322 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
PainJournal
Systematic Review of Observational (behavioral) Measures of Pain for Children and Adolescents Aged 3 to 18 Years
von Baeyer, Carl L., and Lara J. Spagrud. 2007. “Systematic Review of Observational (behavioral) Measures of Pain for Children and Adolescents Aged 3 to 18 Years”. Pain. Ovid Technologies (Wolters Kluwer Health). doi:10.1016/j.pain.2006.08.014.
Nursing in Critical CareJournal
The COMFORT Behavioural Scale and the Modified FLACC Scale in Paediatric Intensive Care
Johansson, Monica, and Eva Kokinsky. 2009. “The COMFORT Behavioural Scale and the Modified FLACC Scale in Paediatric Intensive Care”. Nursing in Critical Care. Wiley. doi:10.1111/j.1478-5153.2009.00323.x.
PainJournal
The Parents’ Postoperative Pain Measure: Replication and Extension to 2–6-year-old Children
Chambers, Christine T, Allen G. Finley, Patrick J McGrath, and Trudi M Walsh. 2003. “The Parents’ Postoperative Pain Measure: Replication and Extension to 2–6-year-old Children”. Pain. Ovid Technologies (Wolters Kluwer Health). doi:10.1016/s0304-3959(03)00256-2.
clinicaltrials.govStudy
Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair
Bryce Weber 2015. "Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03041948.
All > Hernia
~9 spots leftby Apr 2025
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