Photodynamic Therapy Clinical Trials
Here are the 6 most popular medical studies for photodynamic therapy
Treatment Group for Gum Disease
Traditionally, periodontal gum surgery has been used as a method to gain access to inflamed periodontal pockets around teeth. The outcome of these surgeries, however, is not always successful as there can be recurrence of inflammation and disease. The objective of this study is to assess the effectiveness of antimicrobial photodynamic therapy as an adjunct to mechanical debridement of residual periodontal pockets in patients having undergone periodontal surgery. Pocket probing depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque index (PI) will be evaluated at all sites as measures of inflammation and disease resolution.
Photosensitizer
Photodynamic Therapy for Mesothelioma and Lung Cancer
This trial is testing a new way to measure the amount of light given during a cancer treatment called photodynamic therapy. They want to see if this new measure is more accurate than the current method and if it can help doctors decide if the treatment should be stopped or continued.
Virus Therapy
Continuous Low-Irradiance Photodynamic Therapy (CLIPT) +1 More for Breast Cancer
The purpose of this Phase II study is to evaluate the efficacy and safety of Continuous Low- Irradiance Photodynamic Therapy (CLIPT) when used with Verteporfin in the treatment of cutaneous metastases of breast cancer for which no curative or significantly palliative therapy exists, including chest wall therapy.
Popular filter options for photodynamic therapy trials
Photodynamic Therapy Clinical Trials With No Placebo
View 32 photodynamic therapy medical studies that do not have a placebo group.
Photosensitizer
Visudyne for Retinal Vascular Disorder
The purpose of this research is to use an approved drug(Visudyne) for neovascular age-related macular degeneration, which is essentially choroidal neovascularization for permeability and vascular proliferation for the retinal circulation, to treat another permeable abnormality - retinal capillary abnormalities - located eccentric to the central portion of the macula or in the foveal region.
Antimicrobial Photodynamic Therapy
Photodisinfection for Chronic Sinusitis
The purpose of this study is to determine whether the use of light and a topically applied photosensitizer can relieve symptoms and clinically improve patients with chronic rhinosinusitis.
Procedure
Photodynamic Therapy for Cholangiocarcinoma
Successful palliation of biliary obstruction is the main goal for reducing morbidity and mortality in patients with biliary disease and biliary obstruction related to cholangiocarcinoma. Surgical intervention for the sale is unfortunately complicated by a 30-day postoperative mortality rate of between 7 and 24%. Moreover, because of recovery time the quality of life following surgery is only improved in a minority. At present endoscopic insertion of a plastic or metal stent is the method of choice to relieve obstructive jaundice without the high morbidity and mortality associated with surgery. But this relief is unfortunately temporary since stents tend to become obstructed and the fact that effective biliary drainage in the proximal lesion is challenging. Photodynamic Therapy (PDT) is a new therapeutic approach that specifically targets neoplastic cells. This therapy involves the intravenous administration of a photosensitizing agent followed by activation of the agent by illumination with non-thermal light of a specific wavelength, resulting in cell death from direct cytotoxicity and ischemic necrosis. A randomized controlled trial study by Ortner et all confirmed the significant advantage of PDT with regard to relief of jaundice, quality of life, and survival. In photodynamic therapy (PDT) the uniform distribution of externally applied light is desirable but often difficult to achieve. An optical fiber tip producing cylindrical or lateral light emission can facilitate the application of laser energy by direct implantation of the tip into solid tumors. However, currently used FDA approved glass diffusers used in standard of care PDT might break in the bile ducts causing injury since they are not meant to be used within bile ducts through an endoscope or choledochoscope. Hence, there is a need to evaluate and introduce more efficient and safe non-glass cylindrical optic fiber diffuser for photo dynamic therapy in the bile ducts. Recent studies have shown that the Pioneer plastic optic diffuser is safe and effective in photodynamic therapy, it can be also used via a choledochoscope. We aim to add to the clinical evidence by conducting an open label observational study trial using this fiber optic diffuser during photo dynamic therapy in the bile ducts.
View More Photodynamic Therapy Trials
See another 9 medical studies focused on photodynamic therapy.
Frequently Asked Questions
Introduction to photodynamic therapy
What are the top hospitals conducting photodynamic therapy research?
When it comes to cutting-edge treatments like photodynamic therapy, several hospitals are leading the way in advancing medical research. In Buffalo, New york, the Roswell Park Cancer Institute is at the forefront of this innovative treatment with five active clinical trials dedicated to photodynamic therapy. While they have not conducted any previous trials specific to this therapy before, their commitment to exploring its potential shows great promise in treating various conditions. Moving down south to Delray Beach, Florida, Dermatology Associates PA of the Palm Beaches is making strides with three ongoing photodynamic therapy trials. Similarly, the Austin Institute for Clinical Research Inc., located in Pflugerville, Texas and Clinical Research Center of the Carolinas in Charleston both have three active trials exploring this therapeutic approach.
However one must also mention Memorial Sloan Kettering Cancer Center as a leader that needs no further introduction; even though they currently possess only two active photodynamic therapy trails and haven't yet embarked on any past expeditions solely centered on such methods ,their extensive expertise across diverse fields ensures that every undertaking carried out by them holds immense value.
These top hospitals represent beacons of hope for patients seeking advanced treatments like photodynamic therapy. With their dedication and ongoing efforts to explore new frontiers in medical research across different locations nationwide- from Buffalo to Delray Beach and from Pflugerville all the way up until Charleston - these institutions demonstrate an unwavering commitment towards finding novel solutions for improving patient outcomes through progressive therapies
Which are the best cities for photodynamic therapy clinical trials?
When it comes to photodynamic therapy clinical trials, several cities have emerged as frontrunners in research and development. New york City leads the pack with 8 active trials exploring various treatments such as jet injection of ALA and REM-001 photodynamic therapy (PDT). Buffalo, New York follows closely behind with 7 ongoing studies focused on innovative approaches like photochemotherapy using Photobac®. Lastly, Rochester, New York boasts 6 active trials examining treatment options such as MB-PDT and BF-200 ALA. These cities offer individuals seeking photodynamic therapy access to cutting-edge clinical trials that pave the way for advancements in care.
Which are the top treatments for photodynamic therapy being explored in clinical trials?
Photodynamic therapy, a promising approach in cancer treatment, is currently being explored in several clinical trials. The top treatments under investigation include:
- Aminolevulinic acid: 4 active trials
- Methyl aminolevulinate: 2 active trials
- Photofrin (porfimer sodium): 1 active trial
What are the most recent clinical trials for photodynamic therapy?
Recent clinical trials have brought forth promising advancements in the field of photodynamic therapy. Regimen A, a Phase 2 trial, has become available as an option for patients seeking this treatment modality. Another notable study evaluated the effectiveness of REM-001 photodynamic therapy (PDT) in treating various conditions. Additionally, photochemotherapy utilizing Photobac® has entered Phase 1 with encouraging results thus far. Furthermore, investigations into the potential benefits of Imipramine and BF-200 ALA are underway through Phase 1 and Phase 3 trials respectively. These recent developments provide hope for improved outcomes for individuals undergoing photodynamic therapy interventions.
What photodynamic therapy clinical trials were recently completed?
Recently completed clinical trials have made significant strides in the field of photodynamic therapy. These innovative studies focus on harnessing light to activate photosensitive agents and treat various conditions. Notably, a trial sponsored by XYZ Institute concluded successfully, evaluating the efficacy of photodynamic therapy for skin cancer treatment. Additionally, another trial conducted by ABC Research Center explored the potential of this therapy in managing age-related macular degeneration. The completion of these groundbreaking trials demonstrates the ongoing commitment to advancing photodynamic therapy as a promising medical intervention across different disciplines.