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Antibiotic Compound Coating

CeraShield Endotracheal Tube for Ventilator-Associated Pneumonia (CEASEVAP Trial)

N/A

Waitlist Available

Led By John MUSCEDERE, MD

Research Sponsored by Queen's University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Adult critically ill patients with respiratory failure requiring intubation

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during the trial up to 1 year from study start

Awards & highlights

CEASEVAP Trial Summary

This trial tests a new medical device that might reduce the risk of ventilator-associated pneumonia (VAP), which can result in increased duration of mechanical ventilation, increased ICU/hospital stay, increased risk of death and increased health care costs.

Who is the study for?

This trial is for adult critically ill patients with respiratory failure who need intubation but don't already have a tracheostomy or non-study endotracheal tube (ETT) when admitted to the ICU. Patients must consent to participate in research.Check my eligibility

What is being tested?

The study tests a new ETT coated with an antibiotic compound, CeraShield, against standard tubes with secretion drainage. It aims to see if this can prevent ventilator-associated pneumonia by reducing bio-film and bacteria on the ETT.See study design

What are the potential side effects?

Potential side effects are not explicitly listed, but may include reactions to the antibiotic coating such as local irritation or allergic responses. The usual risks of using any ETT also apply.

CEASEVAP Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am an adult in critical condition needing a breathing tube for respiratory failure.

CEASEVAP Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during the trial up to 1 year from study start

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during the trial up to 1 year from study start

This trial's timeline: 3 weeks for screening, Varies for treatment, and during the trial up to 1 year from study start for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Occurrence of Ventilator Associated Pneumonia

Secondary outcome measures

Acceptability of the Intervention

Airway outcomes

Antibiotic Utilization

+5 more

CEASEVAP Trial Design

2Treatment groups

Active Control

Group I: Endotracheal Tube with Subglottic Secretion DrainageActive Control1 Intervention

All patients in this arm will be intubated with an ETT with subglottic secretion drainage

Group II: CeraShield Endotracheal TubeActive Control1 Intervention

All patients in this arm will be intubated with a ceragenin coated ETT

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Queen's UniversityLead Sponsor

365 Previous Clinical Trials

120,017 Total Patients Enrolled

Dr. John MuscedereLead Sponsor

3 Previous Clinical Trials

790 Total Patients Enrolled

John MUSCEDERE, MDPrincipal InvestigatorQueens University

Media Library

CeraShield Endotracheal Tube (Antibiotic Compound Coating) Clinical Trial Eligibility Overview. Trial Name: NCT05761613 — N/A

Bacterial Pneumonia Research Study Groups: Endotracheal Tube with Subglottic Secretion Drainage, CeraShield Endotracheal Tube

Bacterial Pneumonia Clinical Trial 2023: CeraShield Endotracheal Tube Highlights & Side Effects. Trial Name: NCT05761613 — N/A

CeraShield Endotracheal Tube (Antibiotic Compound Coating) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05761613 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any current opportunities for individuals to enroll in this research?

"Data on clinicaltrials.gov shows that this trial is actively seeking patient participants, with the first post being made on February 21st 2023 and an update to it occurring six days later."

Answered by AI

How many volunteers are being enrolled in this clinical trial?

"That is accurate. As per clinicaltrials.gov, this research study commenced on February 21st 2023 and has been amended as recently as February 27th 2023. The trial seeks to enrol 400 participants from 1 distinct medical centre."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Ceragenin Coated Endotracheal Tubes for the Prevention of Ventilator Associated Pneumonia

Dr. John Muscedere 2023. "Ceragenin Coated Endotracheal Tubes for the Prevention of Ventilator Associated Pneumonia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05761613.