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Mini Bronchoalveolar Lavage for Lung Injury

N/A

Recruiting

Research Sponsored by WilliamJanssen

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up days on ventilator 1-2, 4-6 and 8-10

Awards & highlights

Study Summary

This trial will look at how white blood cells respond to lung inflammation in people with ARDS and how testing lung cells can help reduce the time to start treatment for ventilator-associated pneumonia. Participants will receive oxygen, have small amounts of fluid taken from their lungs, and have nasal and blood samples taken.

Who is the study for?

This trial is for ICU patients on mechanical ventilation due to ARDS or similar conditions, expected to remain ventilated for at least 48 hours. It's not suitable for those with chronic lung diseases, recent immunosuppressant use, history of organ transplant, severe bleeding risks, a directive against life-sustaining treatment, morbid state with less than 14 days survival expectancy or pregnancy.Check my eligibility

What is being tested?

The study observes how white blood cells in the lungs respond to inflammation from ARDS. Participants undergo non-bronchoscopic mini bronchoalveolar lavage (miniBAL) where saline is introduced and then removed from the lungs via a catheter for analysis. This helps understand immune responses and may expedite pneumonia treatment initiation.See study design

What are the potential side effects?

Potential side effects include discomfort during the miniBAL procedure and risks associated with pre-oxygenation and fluid introduction into the lungs such as temporary oxygen level changes. Blood draws might cause bruising or infection at the needle site.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ days on ventilator 1-2, 4-6 and 8-10

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~days on ventilator 1-2, 4-6 and 8-10

This trial's timeline: 3 weeks for screening, Varies for treatment, and days on ventilator 1-2, 4-6 and 8-10 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Evaluate host response to ARDS

Macrophage signaling

Recruited versus resident macrophages

+1 more

Secondary outcome measures

Ventilator associated pneumonia (VAP)

Trial Design

1Treatment groups

Experimental Treatment

Group I: Study Population GroupExperimental Treatment1 Intervention

People in the ICU on mechanical ventilation due to a diagnosis of ARDS or any other diagnosis that requires mechanical ventilation (following surgery, sepsis without lung involvement, seizures)

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

National Heart, Lung, and Blood Institute (NHLBI)NIH

3,840 Previous Clinical Trials

47,852,068 Total Patients Enrolled

WilliamJanssenLead Sponsor

Media Library

Study Population Group Clinical Trial Eligibility Overview. Trial Name: NCT05767671 — N/A

Bacterial Pneumonia Research Study Groups: Study Population Group

Bacterial Pneumonia Clinical Trial 2023: Study Population Group Highlights & Side Effects. Trial Name: NCT05767671 — N/A

Study Population Group 2023 Treatment Timeline for Medical Study. Trial Name: NCT05767671 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is geriatric participation being considered for this scientific inquiry?

"This clinical trial calls for patients aged 18 years and above, but not yet 80 years, to join."

Answered by AI

Are there any open vacancies for this trial?

"Indeed, the research displayed on clinicaltrials.gov elucidates that this test is presently recruiting participants. It was initially posted on April 10th 2020 and has been amended most recently on March 2nd 2023. There are 56 needed patients from a single location."

Answered by AI

Am I eligible to take part in this scientific research?

"To partake in this medical study, individuals must be between 18-80 years old and have been diagnosed with acute respiratory distress syndrome. A total of 56 patients are needed for the experiment."

Answered by AI

How many individuals are taking part in the experiment?

"Correct. According to clinicaltrials.gov, this medical trial is actively seeking participants since it was first published on April 10th 2020 and updated most recently on March 2nd 2023. There are 56 individuals required for the study at a single site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Macrophage Programing in Acute Lung Injury: MiniBAL

WilliamJanssen 2020. "Macrophage Programing in Acute Lung Injury: MiniBAL". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05767671.

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