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Ozone Exposure for Lung Function

Phase < 1
Waitlist Available
Research Sponsored by Robert Tighe, MD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 21 days
Awards & highlights

Study Summary

This trial is testing how different environmental and genetic factors may affect lung function. It will screen participants over the course of one day, then have them come back for two days for more testing. This will include a blood draw and a breathing test before and after being exposed to either filtered air or ozone. Then, they will have a bronchoscopy to evaluate the lungs. They will repeat this process once more, 18-20 days later. There will be follow-up phone calls from the study team after each two-day test series. The whole study will last one to one-and-a-half months.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 21 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 21 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Ozone (O3) induced epithelial permeability, as measured by albumin level (ug/mL)
Change in Ozone (O3) induced epithelial permeability, as measured by the level of clara cell secretory protein (ng/mL)
Secondary outcome measures
Change in Ozone O3 induced alterations in bronchoalveolar lavage cytokines and growth factors
Change in Ozone O3 induced alterations in gene expression of airway epithelial cells, and bronchoalveolar lavage cells

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: OzoneExperimental Treatment1 Intervention
Group II: Filtered AirPlacebo Group1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ozone
Not yet FDA approved

Find a Location

Who is running the clinical trial?

Robert Tighe, MDLead Sponsor
2 Previous Clinical Trials
122 Total Patients Enrolled

Media Library

Bronchoscopy Clinical Trial Eligibility Overview. Trial Name: NCT03599206 — Phase < 1
Lung Function Research Study Groups: Filtered Air, Ozone
Lung Function Clinical Trial 2023: Bronchoscopy Highlights & Side Effects. Trial Name: NCT03599206 — Phase < 1
Bronchoscopy 2023 Treatment Timeline for Medical Study. Trial Name: NCT03599206 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What earlier research has been conducted related to Ozone?

"At the moment, there is 1 Phase 3 trial and 4 other studies studying Ozone. These clinical trials are mainly located in Las Palmas De Gran Canaria, yet 6 sites across different locales have begun researching this substance."

Answered by AI

What is the approximate participant count for this clinical experiment?

"Affirmative. Clinicaltrials.gov's records suggest that the trial is currently in recruitment mode, having first been announced on August 16th 2019 and last updated on September 28th 2022. This medical research requires 100 participants across a single site to be recruited."

Answered by AI

Is it possible for me to enroll in this medical experiment?

"In order to qualify for the trial, participants must possess both genetic and environmental factors influencing their lung function while also being between 18-45 years old. Ultimately, 100 individuals will be enrolled in this clinical study."

Answered by AI

Is this research actively seeking participants?

"Affirmative. According to data on clinicaltrials.gov, this experiment is currently accepting participants; it was posted initially on August 16th 2019 and last updated on September 28th 2022. The trial requires a total of 100 volunteers from one medical centre."

Answered by AI

Does this research protocol have an age limit?

"The parameters for participation in this study dictate that the lowest permissible age is 18, with a maximum upper limit of 45."

Answered by AI
~3 spots leftby Mar 2025