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CBT for Uncertainty Tolerance for Multiple Sclerosis (CALMS Trial)

N/A
Waitlist Available
Led By Ivan Molton, PhD
Research Sponsored by University of Washington
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

CALMS Trial Summary

This trial is testing a psychological intervention, CBT-UT, to help people with MS who are struggling to cope with uncertainty. There are three different treatment arms, and participants will receive either CBT for Uncertainty Tolerance, Traditional CBT, or treatment as usual.

Eligible Conditions
  • Multiple Sclerosis

CALMS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Questionnaire: Level of MS Acceptance as measured by the Acceptance of Chronic Health Conditions, MS Version Questionnaire.
Questionnaire: Level of anxiety as measured by the Global Anxiety Disorder-7 scale (GAD-7).
Mental Depression
Secondary outcome measures
Demographic: Biological Sex. Measured by self-report.
Multiple Sclerosis

CALMS Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: CBT-UTExperimental Treatment1 Intervention
Seven telephone-based sessions of cognitive behavioral therapy for uncertainty tolerance (CBT-UT) delivered over seven weeks.
Group II: TAUActive Control1 Intervention
Participant continues with their lives as they normally would.
Group III: tCBTActive Control1 Intervention
Seven telephone-based sessions of traditional cognitive behavioral therapy (tCBT) delivered over seven weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
CBT for Uncertainty Tolerance
2019
N/A
~250

Find a Location

Who is running the clinical trial?

University of WashingtonLead Sponsor
1,743 Previous Clinical Trials
1,847,628 Total Patients Enrolled
23 Trials studying Multiple Sclerosis
3,404 Patients Enrolled for Multiple Sclerosis
National Multiple Sclerosis SocietyOTHER
96 Previous Clinical Trials
9,263 Total Patients Enrolled
94 Trials studying Multiple Sclerosis
8,909 Patients Enrolled for Multiple Sclerosis
Ivan Molton, PhDPrincipal Investigator - University of Washington
University of Washington
1 Previous Clinical Trials
516 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are researchers currently enrolling participants for this experiment?

"Clinicaltrials.gov suggests that this particular research is not open to recruitment at the moment, having been initially posted on October 30th 2019 and most recently updated two years ago. However, there are an abundance of other medical studies actively recruiting patients right now with a total tally of 549 trials."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Coping and Adjusting to Living With Multiple Sclerosis
Ivan Molton 2019. "Coping and Adjusting to Living With Multiple Sclerosis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04300816.
~44 spots leftby May 2025
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