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Behavioral Intervention

Behavioral Weight Loss Treatment for Obesity (REBOOT Trial)

Research Sponsored by Rush University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age ≥18 years old
Obesity (body mass index ≥30 kg/m2)
Must not have
Not fluent in English
History of bariatric surgery, or current engagement in another weight loss therapy
Screening 3 weeks
Treatment Varies
Follow Up months 2, 4, and 6
Awards & highlights


This trial seeks to find out why weight-loss interventions don't work as well for socioeconomically disadvantaged individuals.

Who is the study for?
This trial is for adults over 18 with obesity (BMI ≥30 kg/m2) who fall into specific socioeconomic status (SES) groups. Participants must live within 20 miles of Rush and have phone access. Those with a BMI over 60, severe medical conditions, cognitive impairments, substance abuse issues, or not fluent in English cannot join.Check my eligibility
What is being tested?
The study is examining how daily adversities and 'present bias'—a focus on immediate needs due to unstable environments—affect the success of behavioral weight loss treatments among individuals from different socioeconomic backgrounds.See study design
What are the potential side effects?
Since this is a behavioral treatment study focusing on lifestyle changes rather than medication or surgery, side effects are minimal but may include potential stress or discomfort related to changing long-standing habits.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I am 18 years old or older.
I am considered obese based on my BMI.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
I am not fluent in English.
I have had weight loss surgery or am currently trying to lose weight through another method.
I do not have severe health issues like advanced heart failure, cancer, or kidney failure that would prevent me from joining.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~months 2, 4, and 6
This trial's timeline: 3 weeks for screening, Varies for treatment, and months 2, 4, and 6 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Weight change
Secondary outcome measures
Adherence to dietary self-monitoring
Adherence to physical activity recommendations
Frequency of dietary lapses

Trial Design

1Treatment groups
Experimental Treatment
Group I: Standard-of-care behavioral weight loss treatmentExperimental Treatment1 Intervention
6-months of group-based behavioral weight loss treatment following the Centers for Disease Control and Prevention Prevent T2 curriculum.

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for obesity include behavioral weight loss interventions and pharmacotherapy. Behavioral interventions focus on modifying eating and physical activity habits through self-monitoring, goal setting, and addressing cognitive distortions, which help patients develop healthier behaviors and cope with adverse daily experiences and present bias. Pharmacotherapy, such as GLP-1 receptor agonists like liraglutide and semaglutide, reduces appetite and increases satiety, aiding in caloric intake management. Understanding these mechanisms helps obesity patients select the most suitable treatment based on their unique needs and challenges.
Implementing family-based behavioral treatment in the pediatric primary care setting: Design of the PLAN study.Psychological approaches to chronic pain management: evidence and challenges.From ideas to efficacy: The ORBIT model for developing behavioral treatments for chronic diseases.

Find a Location

Who is running the clinical trial?

Rush University Medical CenterLead Sponsor
426 Previous Clinical Trials
156,982 Total Patients Enrolled
13 Trials studying Obesity
1,231 Patients Enrolled for Obesity

Media Library

Behavioral weight loss treatment (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05326477 — N/A
Obesity Research Study Groups: Standard-of-care behavioral weight loss treatment
Obesity Clinical Trial 2023: Behavioral weight loss treatment Highlights & Side Effects. Trial Name: NCT05326477 — N/A
Behavioral weight loss treatment (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05326477 — N/A
~153 spots leftby Jun 2027