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Vector Control Strategies for Malaria

N/A
Recruiting
Led By Guiyun Yan, Ph.D.
Research Sponsored by University of California, Irvine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up vector density will be monitored for up to 60 months
Awards & highlights

Study Summary

This trial is testing different vector control methods to find the best way to reduce malaria incidence and infection in Kenya.

Who is the study for?
This trial is for households in Kenya with residents willing to consent to participate. It includes adults and minors who agree to the intervention and survey, as well as those present during health facility visits or active case detection efforts. Households are excluded if no adult is home after multiple visits or if vacant.Check my eligibility
What is being tested?
The study tests different malaria control methods like microbial larvicides, indoor spraying, and various insecticidal nets. Using a SMART design, it aims to find the best strategy based on local transmission risks and vector ecology by comparing their effectiveness in reducing malaria.See study design
What are the potential side effects?
While specific side effects are not detailed here, interventions may include typical reactions to insecticides such as skin irritation or respiratory issues among sensitive individuals.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~vector density will be monitored for up to 60 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and vector density will be monitored for up to 60 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Annual clinical malaria incidence rate
Secondary outcome measures
Malaria infection prevalence
Malaria transmission intensity
Malaria vector density

Trial Design

7Treatment groups
Experimental Treatment
Placebo Group
Group I: Piperonyl butoxide-treated LLINExperimental Treatment1 Intervention
All participants will received piperonyl butoxide-treated LLINs (PBO-LLINs) at Stage 1 and Stage 2 interventions provided that PBO-LLINs are effective at Stage 1 interventions. Each household will be provided on PBO-LLIN per two people with appropriate eduction. PBO-LLIN: Olyset Plus, containing 2% permethrin and 1% PBO.
Group II: PBO-LLIN plus larval source managementExperimental Treatment2 Interventions
All participants will received piperonyl butoxide-treated LLINs (PBO-LLINs) at Stage 1, however, Stage 1 intervention is not effective. All participants will received PBO-LLINs plus larval source management (LSM) at Stage 2. LSM will be implemented in selected clusters, including both physical and chemical methods by physical filling or removal of temporary larval habitats and larviciding of semi-permanent and permanent habitats, per the National Malaria Strategic Plan of Kenya. We will use the long-lasting microbial larvicides manufactured by Central Life Sciences. Semi-permanent and permanent habitats will be treated with FourStar® 180-day Briquets using the recommended dosage of 100 ft2 water surface per briquet.
Group III: PBO-LLIN plus enhanced methodsExperimental Treatment1 Intervention
All participants will received piperonyl butoxide-treated LLINs (PBO-LLINs) at Stage 1, however, Stage 1 intervention is not effective. All participants will received PBO-LLINs plus an enhanced intervention at Stage 2. The enhanced intervention is determined by machine learning method.
Group IV: LLIN+IRS+LSMExperimental Treatment3 Interventions
All participants will received regular LLINs plus IRS at Stage 1, provided that LLIN+IRS is not effective. LSM will be added on these clusters at Stage 2 interventions. LSM at Stage 2 will be the long-lasting microbial larvicides manufactured by Central Life Sciences. Semi-permanent and permanent habitats will be treated with FourStar® 180-day Briquets using the recommended dosage of 100 ft2 water surface per briquet.
Group V: LLIN+IRS plus enhanced methodExperimental Treatment2 Interventions
All participants will received regular LLINs plus IRS at Stage 1, provided that LLIN+IRS is not effective. Enhanced method will be added on these clusters at Stage 2 interventions.The enhanced intervention is determined by machine learning method.
Group VI: LLIN plus indoor residual sprayingExperimental Treatment2 Interventions
All participants will received regular LLINs plus indoor residual spraying (IRS) (LLIN+IRS) at Stage 1 and Stage 2 interventions provided that LLIN+IRS is effective at Stage 1 interventions. For LLIN+IRS clusters, each dwelling's interior walls and ceilings will be sprayed with micro-encapsulated pirimiphos-methyl (Actellic 300CS) at the recommended dosage of 1g/m² and at the recommended frequency of once a year.
Group VII: Regular long-lasting insecticidal netsPlacebo Group1 Intervention
All participants will have LLIN coverage through routine MoH distribution of long-lasting insecticidal nets (LLINs), no other interventions will be applied. Regular LLIN: Olyset nets containing 2% permethrin or PermaNet 2.0 containing 1.8 and 1.4 g/kg, respectively, for 75 and 100 denier yarn.

Find a Location

Who is running the clinical trial?

University of California, IrvineLead Sponsor
542 Previous Clinical Trials
1,799,129 Total Patients Enrolled
Guiyun Yan, Ph.D.Principal InvestigatorUniversity of California at Irvine
1 Previous Clinical Trials
240,000 Total Patients Enrolled
John Githure, Ph.D.Study DirectorTom-Mboya University, Kenya

Media Library

Indoor residual spraying with micro-encapsulated pirimiphos-methyl Clinical Trial Eligibility Overview. Trial Name: NCT04182126 — N/A
Integrated Vector Management Research Study Groups: LLIN+IRS+LSM, LLIN+IRS plus enhanced method, PBO-LLIN plus larval source management, Regular long-lasting insecticidal nets, LLIN plus indoor residual spraying, PBO-LLIN plus enhanced methods, Piperonyl butoxide-treated LLIN
Integrated Vector Management Clinical Trial 2023: Indoor residual spraying with micro-encapsulated pirimiphos-methyl Highlights & Side Effects. Trial Name: NCT04182126 — N/A
Indoor residual spraying with micro-encapsulated pirimiphos-methyl 2023 Treatment Timeline for Medical Study. Trial Name: NCT04182126 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies for individuals to join this experiment?

"As per clinicaltrials.gov, recruitment for this medical trial is in progress. It was initially posted on December 1st 2019 and last updated June 29th 2021."

Answered by AI

Who else is applying?

What state do they live in?
California
How old are they?
18 - 65
What site did they apply to?
Tom-Mboya University College, Maseno University
What portion of applicants met pre-screening criteria?
Met criteria
~23038 spots leftby Apr 2025