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Metabolic Tracers for Kidney Cancer

N/A

Recruiting

Led By Vitaly Margulis, MD

Research Sponsored by University of Texas Southwestern Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients must have radiographic evidence of known or probable kidney or urothelial cancer requiring surgical biopsy or excision.

Age ≥ 18 years

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 5 years

Awards & highlights

Study Summary

This trial is studying the metabolism of kidney cancers to see how they use fuel to grow. People with kidney cancer who are having surgery or a biopsy can participate.

Who is the study for?

Adults with probable or confirmed kidney or urothelial cancer needing surgery can join. They must understand and sign consent, and may be in other trials if approved by the lead doctor. Not for those with uncontrolled diabetes (if getting a tracer infusion), pregnant/breastfeeding women, or non-surgical candidates.Check my eligibility

What is being tested?

The study is examining how kidney cancers metabolize different nutrients during surgery using labeled tracers like glucose and lactate. Participants will receive these through an IV to track tumor fuel use without affecting their standard treatment.See study design

What are the potential side effects?

Since this trial involves observation of metabolism rather than testing new drugs, side effects are minimal but may include discomfort from IV placement and potential reactions to the nutrient tracers used.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I need a biopsy or surgery for my suspected kidney or bladder cancer.

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I am 18 years old or older.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Percent of 13C isotopologue distributions

Trial Design

5Treatment groups

Experimental Treatment

Group I: 13C-LactateExperimental Treatment1 Intervention

Group II: 13C-GlutamineExperimental Treatment1 Intervention

Group III: 13C-GlucoseExperimental Treatment1 Intervention

Group IV: 13C-FructoseExperimental Treatment1 Intervention

Group V: 13C-AcetateExperimental Treatment1 Intervention

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Texas Southwestern Medical CenterLead Sponsor

1,051 Previous Clinical Trials

1,054,159 Total Patients Enrolled

National Cancer Institute (NCI)NIH

13,692 Previous Clinical Trials

40,929,375 Total Patients Enrolled

Howard Hughes Medical InstituteOTHER

3 Previous Clinical Trials

23,902 Total Patients Enrolled

Media Library

13C-Acetate Clinical Trial Eligibility Overview. Trial Name: NCT04623502 — N/A

Kidney Cancer Research Study Groups: 13C-Fructose, 13C-Lactate, 13C-Glucose, 13C-Acetate, 13C-Glutamine

Kidney Cancer Clinical Trial 2023: 13C-Acetate Highlights & Side Effects. Trial Name: NCT04623502 — N/A

13C-Acetate 2023 Treatment Timeline for Medical Study. Trial Name: NCT04623502 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the current size of the participant cohort for this experiment?

"Affirmative. Clinicaltrials.gov reveals that this clinical trial is actively enrolling participants, which began on September 30th 2019 and was most recently modified on December 1st 2022. The research aims to recruit 600 individuals from a single location."

Answered by AI

Is enrollment open for participation in this clinical experiment?

"Affirmative. According to information available on clinicaltrials.gov, this medical trial is actively recruiting and was first posted on September 30th 2019 with a recent update dated December 1st 2022. The research requires 600 participants at only one site of study."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy

Vitaly Margulis 2019. "An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04623502.