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High Intensity Interval Training for Kidney Failure

N/A

Waitlist Available

Led By Francesc Marti, PhD

Research Sponsored by Francesc Marti

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline- and at 12 weeks post-hiit intervention

Awards & highlights

Study Summary

This trial is looking at the effect of high-intensity interval training (HIIT) on regulatory T cells (Tregs). Tregs are a small population of T cells that play a fundamental role in the maintenance of the immune homeostasis. This trial will determine if HIIT increases the frequency and quality of peripheral Treg cells.

Eligible Conditions

Kidney Failure

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline- and at 12 weeks post-hiit intervention

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline- and at 12 weeks post-hiit intervention

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline- and at 12 weeks post-hiit intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Interventional procedure

Body Weight Changes

Change from baseline concentration of circulating Regulatory T cells (Tregs) in blood at 12 weeks post HIIT intervention

+1 more

Secondary outcome measures

Change from baseline Blood Glucose at 12 weeks post HIIT intervention

Change from baseline Cell membrane CD36 at 12 weeks post HIIT intervention

Change from baseline Cell membrane GLUT1 at 12 weeks post HIIT intervention

+15 more

Other outcome measures

Change from baseline Cell membrane 41BB at 12 weeks post HIIT intervention

Change from baseline Cell membrane CCR2 at 12 weeks post HIIT intervention

Change from baseline Cell membrane CCR4 at 12 weeks post HIIT intervention

+31 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: All subjects will be in one armExperimental Treatment1 Intervention

Both Lean and Obese, End-Stage Renal Disease (ESRD) patients and normal volunteers will be in one arm, that will receive the High Intensity Interval Training intervention.

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Who is running the clinical trial?

Francesc MartiLead Sponsor

Francesc Marti, PhDPrincipal InvestigatorUniversity of Kentucky, College of Medicine / Transplant Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is eligibility for this clinical experiment limited to individuals under 45 years of age?

"The trial is open to participants aged 18 to 65. For those under the age of 18, there are 13 trials available, and 174 exist for people over 65 years old."

Answered by AI

Is admission to this research still available?

"The clinicaltrials.gov listing of this trial reveals that it is not actively seeking participants, having last been updated on February 14th 2022. Nevertheless, there are 180 other studies currently recruiting patients at the moment."

Answered by AI

May I register as a participant in this research trial?

"This clinical trial is recruiting 150 individuals between the ages of 18 and 65 who have been diagnosed with end stage renal disease (ESRD). In addition, participants must possess a Body Mass Index that falls within the range of 18.5-25 or above 30 to assess how High Intensity Interval Training affects those categorized as "lean" (BMI range 18.5-25) versus "obese" (BMI >30), in combination with having less than 5,000 steps per day indicative of sedentary lifestyle."

Answered by AI

What is the intended outcome of this study?

"This clinical trial will assess the primary outcome of Change from baseline Serum Adiponectin at 12 weeks post HIIT intervention, as well as various secondary outcomes such as modifications in Low Density Lipoprotein (LDL), concentrations of serologic cytokines/growth factors/metabolites, and Cell membrane TIGIT. These metrics are all measured over a Baseline- to 12 week post-HIIT interval."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

High-Intensity Interval Training and Regulatory T Cells

Francesc Marti 2023. "High-Intensity Interval Training and Regulatory T Cells". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04774484.