Reversal of Botulinum Neurotoxin Injection Related Dysphonia With Pyridostigmine
Recruiting in Palo Alto (17 mi)
Overseen byBenjamin Rubinstein, MD
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 4
Waitlist Available
Sponsor: Eastern Virginia Medical School
No Placebo Group
Prior Safety Data
Trial Summary
What is the purpose of this trial?This trial tests if pyridostigmine can improve voice quality in patients with spasmodic dysphonia who have a breathy voice after their usual treatment. The medication helps muscles work better, which might enhance their voice.
Eligibility Criteria
Inclusion Criteria
Males and Females Aged 21-100
You have an upcoming appointment for Botulinum Neurotoxin (BoNT) treatment for Spasmodic Dysphonia (SD).
Exclusion Criteria
You have kidney or heart problems that could affect your ability to participate in the study.
You have a condition called Spasmodic Dysphonia with Superimposed Vocal Tremor.
Subjects who are Pregnant or Lactating
Participant Groups
1Treatment groups
Experimental Treatment
Group I: Pyridostigmine (Mestinon)Experimental Treatment1 Intervention
Pyridostigmine (Mestinon) will be assigned to patients in this arm.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Eastern Virginia Medical School Ear, Nose, and Throat SurgeonsNorfolk, VA
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Who Is Running the Clinical Trial?
Eastern Virginia Medical SchoolLead Sponsor