Pyridostigmine Bromide 60 Milligrams (mg) for Hoarseness

Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Eastern Virginia Medical School Ear, Nose, and Throat Surgeons, Norfolk, VAHoarseness+2 MorePyridostigmine Bromide 60 Milligrams (mg) - Drug
Eligibility
21 - 100
All Sexes
What conditions do you have?
Select

Study Summary

This trial will test if a drug used to treat botulism can also help people with spasmodic dysphonia, a condition that causes involuntary muscle spasms in the voice box.

Eligible Conditions
  • Hoarseness
  • Spastic Dysphonia
  • Spasmodic Dysphonia

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Study Objectives

4 Primary · 0 Secondary · Reporting Duration: 15 Minutes

15 Minutes
Adapted Borg Scale Pre- and Post-Pyridostigmine (Mestinon)
CAPE-V Pre- and Post-Pyridostigmine (Mestinon)
Glottal Function Index Pre- and Post-Pyridostigmine (Mestinon)
Rainbow Passage Reading Pre- and Post-Pyridostigmine (Mestinon)

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

1 Treatment Group

Pyridostigmine (Mestinon)
1 of 1

Experimental Treatment

10 Total Participants · 1 Treatment Group

Primary Treatment: Pyridostigmine Bromide 60 Milligrams (mg) · No Placebo Group · Phase 4

Pyridostigmine (Mestinon)
Drug
Experimental Group · 1 Intervention: Pyridostigmine Bromide 60 Milligrams (mg) · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 15 minutes

Who is running the clinical trial?

Eastern Virginia Medical SchoolLead Sponsor
65 Previous Clinical Trials
10,283 Total Patients Enrolled
Benjamin Rubinstein, MDPrincipal InvestigatorEastern Virginia Medical School Department of Otolaryngology - Head and Neck Surgery
1 Previous Clinical Trials
40 Total Patients Enrolled

Eligibility Criteria

Age 21 - 100 · All Participants · 2 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have an upcoming appointment for Botulinum Neurotoxin (BoNT) treatment for Spasmodic Dysphonia (SD).

Frequently Asked Questions

Has research been conducted using Pyridostigmine Bromide 60 Milligrams (mg) in the past?

"Currently, there are 4 active clinical trials researching the effects of Pyridostigmine Bromide 60 Milligrams (mg) with none in Phase 3 yet. Most of these studies take place at locations around Nashville, Tennessee but additional sites are being utilized for this research as well." - Anonymous Online Contributor

Unverified Answer

Is participation in this research open to volunteers?

"This dysphonia research trial invites 10 participants aged between 21 and 100, regardless of gender. Eligibility is defined by the age range specified above." - Anonymous Online Contributor

Unverified Answer

What is the current participant tally for this clinical experiment?

"Affirmative, clinicaltrials.gov provides evidence that this trial is actively recruiting participants since its inception on May 20th 2021 and last update on July 25th 2022. Ten patients are being sought at single medical site for the experiment." - Anonymous Online Contributor

Unverified Answer

Has Pyridostigmine Bromide 60 Milligrams (mg) been granted regulatory approval?

"As this is a Phase 4 trial, signifying approval of Pyridostigmine Bromide 60 Milligrams (mg), it has been assessed as having the highest safety rating of 3." - Anonymous Online Contributor

Unverified Answer

Is the maximum age limit for this trial set at 40 years or below?

"The cut-off age for individuals to be included in this medical trial is 21 and 100 years old. There are 5 trials specifically designed with participants under 18, while 49 cater to those aged 65 or over." - Anonymous Online Contributor

Unverified Answer

Are there still vacancies available for those wishing to participate in this experiment?

"Affirmative. According to the clinicaltrials.gov website, this investigation is still looking for participants after being first posted on May 20th 2021 and last updated on July 25th 2022. 10 people need to be enrolled from 1 medical hub." - Anonymous Online Contributor

Unverified Answer

To what medical conditions has Pyridostigmine Bromide 60 Milligrams (mg) been linked with therapeutic benefits?

"Pyridostigmine Bromide 60 Milligrams (mg) can be prescribed for patients struggling with myasthenia gravis, dyschezia, and orthostatic syncope." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.