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Serial PRP injections for Hoarseness

N/A

Waitlist Available

Led By Michael Johns, MD

Research Sponsored by University of Southern California

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 4 months

Awards & highlights

Study Summary

This trial will test whether four monthly injections of platelet-rich plasma can improve voice quality in people with vocal fold atrophy, scarring, or sulcus vocalis.

Eligible Conditions

Vocal Fold Scar
Presbylarynx
Hoarseness
Laryngeal Atrophy
Vocal Cord Atrophy
Presbylarynges
Sulcus Vocalis

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 4 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~4 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Incidence of Treatment-Emergent Adverse Events as assessed by FDA/CBER Adverse Event Severity Grading Scale

Secondary outcome measures

Objective Vocal Quality as assessed by experts using the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) instrument

Diagnostic Imaging

Voice-Related Quality of Life as assessed by Voice Handicap Index-10 (VHI-10) and Vocal Fatigue Index (VFI)

Trial Design

1Treatment groups

Experimental Treatment

Group I: Serial PRP injectionsExperimental Treatment1 Intervention

This arm will receive experimental intervention of serial monthly platelet-rich plasma (PRP) injections to a unilateral vocal fold mucosa for a total of 4 injections.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Serial PRP injections

2020

N/A

~20

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of Southern CaliforniaLead Sponsor

906 Previous Clinical Trials

1,596,143 Total Patients Enrolled

Michael Johns, MDPrincipal InvestigatorUniversity of Southern California

1 Previous Clinical Trials

18 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any opportunities for patients to enroll in this trial at present?

"Based on the information hosted by clinicaltrials.gov, this trial is in a period of dormancy and not actively recruiting participants at this time. This research was first posted on February 18th 2020 but has been updated as recently as May 5th 2022. However, there are still 213 other trials that require volunteers right away."

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