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Serial PRP injections for Hoarseness

Waitlist Available
Led By Michael Johns, MD
Research Sponsored by University of Southern California
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Screening 3 weeks
Treatment Varies
Follow Up 4 months
Awards & highlights


This trial will test whether four monthly injections of platelet-rich plasma can improve voice quality in people with vocal fold atrophy, scarring, or sulcus vocalis.

Eligible Conditions
  • Vocal Fold Scar
  • Presbylarynx
  • Hoarseness
  • Laryngeal Atrophy
  • Vocal Cord Atrophy
  • Presbylarynges
  • Sulcus Vocalis


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Incidence of Treatment-Emergent Adverse Events as assessed by FDA/CBER Adverse Event Severity Grading Scale
Secondary outcome measures
Objective Vocal Quality as assessed by experts using the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) instrument
Diagnostic Imaging
Voice-Related Quality of Life as assessed by Voice Handicap Index-10 (VHI-10) and Vocal Fatigue Index (VFI)

Trial Design

1Treatment groups
Experimental Treatment
Group I: Serial PRP injectionsExperimental Treatment1 Intervention
This arm will receive experimental intervention of serial monthly platelet-rich plasma (PRP) injections to a unilateral vocal fold mucosa for a total of 4 injections.
First Studied
Drug Approval Stage
How many patients have taken this drug
Serial PRP injections

Find a Location

Who is running the clinical trial?

University of Southern CaliforniaLead Sponsor
919 Previous Clinical Trials
1,611,427 Total Patients Enrolled
Michael Johns, MDPrincipal InvestigatorUniversity of Southern California
1 Previous Clinical Trials
18 Total Patients Enrolled
~3 spots leftby Jul 2025