Exercise Training for Right Ventricular Dysfunction in COPD
What You Need to Know Before You Apply
What is the purpose of this trial?
This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response to pulmonary hypertension (high pressure in the lungs) during rest and exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot have changed your COPD therapy in the 3 weeks before joining. If you are using systemic corticosteroids, you must not have used them in the 3 months before joining.
Is exercise training safe for people with COPD?
How does exercise training differ from other treatments for right ventricular dysfunction in COPD?
Exercise training is unique because it directly targets the improvement of exercise tolerance and right ventricular function through physical activity, rather than relying on medication. It is a key component of pulmonary rehabilitation, which is a standard care approach for COPD, and has been shown to improve both exercise performance and quality of life by addressing the underlying muscle dysfunction and breathlessness associated with the condition.25678
What data supports the effectiveness of the treatment Exercise training for Right Ventricular Dysfunction in COPD?
Exercise training is shown to improve exercise capacity, reduce breathlessness, and enhance quality of life in patients with COPD, even though their lung function remains unchanged. It is a key part of pulmonary rehabilitation, helping patients manage symptoms and improve their overall health.123910
Who Is on the Research Team?
Lindsay Forbes, MD
Principal Investigator
University of Colorado, Denver
Are You a Good Fit for This Trial?
This trial is for adults with COPD, confirmed by specific lung function tests and signs of pulmonary artery enlargement. Participants should not have had a recent COPD flare-up or changes in treatment, must be able to exercise on a bike, and not already doing regular intense workouts. They can't join if they have severe heart issues, untreated sleep apnea, extreme body weight, certain blood conditions or are pregnant.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Testing at Rest and During Exercise
Participants will complete testing at rest and during exercise to identify patterns of right ventricular dysfunction
Exercise Training Program (Optional)
Participants may opt into an exercise training program followed by repeat testing to determine the impact on right ventricular dysfunction
Follow-up
Participants are monitored for safety and effectiveness after the exercise training program
What Are the Treatments Tested in This Trial?
Interventions
- Exercise training
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Colorado, Denver
Lead Sponsor