Microdoses of Activity for Chronic Obstructive Pulmonary Disease (COPD)

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Chronic Obstructive Pulmonary Disease (COPD)+4 MoreMicrodoses of activity - Behavioral
Eligibility
Any Age
All Sexes
What conditions do you have?
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Study Summary

Chronic obstructive pulmonary disease (COPD) is a disease of the lungs that makes it hard for people to breath. Those with COPD spend considerably more time sitting and lying and less time performing physical activity than healthy individuals. Those who are the most sedentary have a greater risk of heart and blood vessel disease, which may lead to an early death. This project will investigate the effect of sitting still for 3 hours on blood vessel health in individuals with COPD. It will also investigate whether breaking up the amount of time patients sit with regular short bouts of walking (5 minutes each hour) at a comfortable pace chosen by the patient can have a positive effect on maintaining the health of their blood vessels. It is hypothesized that blood vessel health will be worse after 3 hours of sitting compared to when the sitting is broken up by short bouts of walking.

Eligible Conditions
  • Chronic Obstructive Pulmonary Disease (COPD)
  • Cardiovascular Disease
  • Endothelial Dysfunction
  • High Blood Pressure
  • Vascular Stiffness

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 2 Secondary · Reporting Duration: Within 30, 60, 90, 120, 150 and 180 minutes of sitting (Day1) or within 30, 60, 90, 120, 150 and 180 minutes of sitting broken up by micro-doses of physical activity (Day 2). Days performed in a randomized order.

Day 2
Time course of change in endothelial function of the superficial femoral artery
Day 2
Difference in 24-hour ambulatory blood pressure between the two conditions
Day 2
Change in central arterial stiffness
Body Weight Changes
Change in superficial femoral artery blood flow patterns
Change in superficial femoral artery endothelial function
Day 2
Time course of change in superficial femoral artery blood flow patterns

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Control
1 of 2
Microdoses of Activity
1 of 2

Active Control

Experimental Treatment

20 Total Participants · 2 Treatment Groups

Primary Treatment: Microdoses of Activity · No Placebo Group · N/A

Microdoses of Activity
Behavioral
Experimental Group · 1 Intervention: Microdoses of activity · Intervention Types: Behavioral
ControlNoIntervention Group · 1 Intervention: Control · Intervention Types:

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: within 30, 60, 90, 120, 150 and 180 minutes of sitting (day1) or within 30, 60, 90, 120, 150 and 180 minutes of sitting broken up by micro-doses of physical activity (day 2). days performed in a randomized order.

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,327 Previous Clinical Trials
1,534,567 Total Patients Enrolled
13 Trials studying Chronic Obstructive Pulmonary Disease (COPD)
3,450 Patients Enrolled for Chronic Obstructive Pulmonary Disease (COPD)

Eligibility Criteria

Age Any Age · All Participants · 1 Total Inclusion Criteria

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