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Histone Deacetylase Inhibitor

PVX-410 for Multiple Myeloma

Phase 1
Waitlist Available
Led By Noopur Raje, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights

Study Summary

This trialis testing a therapy to treat Multiple Myeloma, using drugs Lenalidomide, Citarinostat and PVX-410.

Eligible Conditions
  • Multiple Myeloma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Safety And Tolerability Of The PVX-410 Tumor Vaccine Regimen
Secondary outcome measures
Change In Free Light Chain (FLC)
Body Weight Changes
Change In Urinary FLC Level
+2 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: PVX-410 + Citarinostat + LenalidomideExperimental Treatment4 Interventions
Participants will receive: 6 biweekly doses of PVX-410 6 biweekly doses of Hiltonol 3 monthly cycles of Citarinostat 3 monthly cycles of Lenalidomide
Group II: PVX-410 + CitarinostatExperimental Treatment3 Interventions
Participants will receive: 6 biweekly doses of PVX-410 6 biweekly doses of Hiltonol 3 monthly cycles of Citarinostat
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Hiltonol
2015
Completed Phase 2
~110
Lenalidomide
FDA approved
PVX-410
2012
Completed Phase 1
~30

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,928 Previous Clinical Trials
13,198,336 Total Patients Enrolled
35 Trials studying Multiple Myeloma
2,649 Patients Enrolled for Multiple Myeloma
CelgeneIndustry Sponsor
636 Previous Clinical Trials
128,952 Total Patients Enrolled
142 Trials studying Multiple Myeloma
40,844 Patients Enrolled for Multiple Myeloma
OncoPep, Inc.Industry Sponsor
3 Previous Clinical Trials
97 Total Patients Enrolled
1 Trials studying Multiple Myeloma
22 Patients Enrolled for Multiple Myeloma

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
A Study of PVX-410, a Cancer Vaccine, and Citarinostat +/- Lenalidomide for Smoldering MM
Noopur Raje 2017. "A Study of PVX-410, a Cancer Vaccine, and Citarinostat +/- Lenalidomide for Smoldering MM". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02886065.
All > Lenalidomide > Revlimid
~2 spots leftby Apr 2025
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