40 Participants Needed

Exercise Training for Heart Failure

ED
RB
Overseen ByRobyn Bryde, MD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Mayo Clinic
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 1 JurisdictionThis treatment is already approved in other countries

Trial Summary

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it requires that your condition and medications have been stable for more than 3 months.

What data supports the effectiveness of the treatment Exercise Training for Heart Failure?

Research shows that regular exercise training can safely improve exercise tolerance, quality of life, and reduce symptoms in heart failure patients. It is a recommended treatment that can enhance health outcomes when tailored to individual needs and performed consistently.12345

Is exercise training safe for heart failure patients?

Exercise training is generally considered safe for heart failure patients when done under supervision and with proper evaluation. Studies have shown that it can improve fitness and quality of life, and it is recommended in current guidelines for heart failure management.678910

How is exercise training different from other treatments for heart failure?

Exercise training for heart failure is unique because it combines physical activity with lifestyle changes to improve heart function and quality of life. Unlike medications or surgeries, it involves regular aerobic and resistance exercises tailored to each patient's ability, which can enhance exercise capacity, reduce symptoms, and potentially lower hospitalization rates.2591112

What is the purpose of this trial?

This research study is being done to find out if exercise therapy can help improve the heart function, overall health, and quality of life of patients with pulmonary hypertension caused by heart failure.

Research Team

BJ

Bryan Taylor, PhD

Principal Investigator

Mayo Clinic

Eligibility Criteria

This trial is for heart failure patients with reduced heart function (LVEF < 40%) who've been stable for over 3 months and can exercise on a bike or treadmill. It's not for those in the most severe stage of heart failure, pregnant women, individuals with certain other health issues like severe obesity or uncontrolled diabetes, or conditions that limit exercise.

Inclusion Criteria

My health condition has been stable for over 3 months.
My heart condition allows me to perform daily activities with slight to moderate limitations.
Your heart's pumping function is very weak.
See 1 more

Exclusion Criteria

I have a condition that limits my ability to exercise.
Pregnant or nursing women
I have conditions like severe obesity, uncontrolled high blood pressure, type 2 diabetes, or severe COPD.
See 2 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Exercise Testing

Participants undergo exercise testing to assess baseline cardiopulmonary function

1 week
1 visit (in-person)

Treatment

Participants are randomized to either 10 weeks of supervised exercise training or continue standard medical care

10 weeks
30 visits (in-person) for exercise group

Follow-up

Participants are monitored for changes in pulmonary and cardiac function after the intervention

4 weeks

Treatment Details

Interventions

  • Exercise Training
Trial Overview The study is testing if regular exercise can improve how well the heart works, overall health, and life quality in people with pulmonary hypertension due to heart failure. Participants will follow an exercise program using bikes or treadmills.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Exercise TrainingExperimental Treatment1 Intervention
Two sets of exercise testing (before and after) 10 weeks of supervised exercise training (3 sessions per week) at Mayo Clinic Florida.
Group II: Control GroupsActive Control1 Intervention
Two sets of exercise testing while continuing with standard medical care in between.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+

Florida Heart Research Institute

Collaborator

Trials
3
Recruited
220+

Findings from Research

Regular exercise training is highly recommended for heart failure patients, supported by strong evidence, yet many patients remain inactive due to various barriers.
Home telerehabilitation is proposed as an effective solution to encourage physical activity among heart failure patients, addressing the limitations of traditional outpatient rehabilitation.
How to do: telerehabilitation in heart failure patients.Piotrowicz, E.[2019]
Recent studies indicate that regular exercise training is safe and effective for patients with stable Class II and III heart failure, improving exercise tolerance and quality of life.
Moderate physical activity, such as 30 to 60 minutes of walking or cycling 3 to 5 days a week, can help reverse some muscle abnormalities and reduce stress on the heart, but more research is needed to fully understand its impact on long-term health outcomes.
Exercise training in heart failure.Afzal, A., Brawner, CA., Keteyian, SJ.[2019]
Exercise training is a safe and effective treatment for patients with heart failure, significantly improving their quality of life and functioning, yet it is underutilized despite being a guideline-recommended intervention.
A tailored exercise program that considers individual patient preferences and physiological capabilities is crucial for success, highlighting the need to overcome barriers related to patient access, physician awareness, and insurance coverage.
Exercise And Heart Failure: Advancing Knowledge And Improving Care.Alvarez, P., Hannawi, B., Guha, A.[2018]

References

How to do: telerehabilitation in heart failure patients. [2019]
Exercise training in heart failure. [2019]
Exercise And Heart Failure: Advancing Knowledge And Improving Care. [2018]
[Exercise training as a key component of heart failure therapy]. [2018]
[Role of rehabilitation in the treatment of chronic heart insufficiency]. [2019]
Exercise training in patients with heart failure: clinical outcomes, safety, and indications. [2021]
Safety and effects of physical training in chronic heart failure. Results of the Chronic Heart Failure and Graded Exercise study (CHANGE) [2007]
Cardiac rehabilitation: a comprehensive program for the management of heart failure. [2019]
Exercise training in heart failure. [2020]
[Exercise Training and Physical Activity in Patients with Heart Failure]. [2018]
Effects of Concurrent, Within-Session, Aerobic and Resistance Exercise Training on Functional Capacity and Muscle Performance in Elderly Male Patients with Chronic Heart Failure. [2023]
[Exercise in heart failure - additional effect to medication?]. [2011]
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