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Uterotonic Agent

High dose oxytocin + propranolol for Postpartum Hemorrhage

N/A
Waitlist Available
Led By Mrinalini Balki, MD
Research Sponsored by Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 hours
Awards & highlights

Study Summary

This trial is investigating whether propranolol can help improve labor induction/augmentation and treatment of postpartum hemorrhage (PPH).

Eligible Conditions
  • Postpartum Hemorrhage

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Motility index
Secondary outcome measures
Amplitude of contraction
Frequency of contraction
Integrated area under response curve (AUC)

Trial Design

6Treatment groups
Active Control
Group I: High dose oxytocin + propranololActive Control2 Interventions
The myometrial samples are bathed in an oxytocin solution (10 -5M), followed by increasing concentrations of oxytocin (from 10 -8M to 10 -5M) plus propranolol (10 -6M)
Group II: Propranolol + low dose oxytocinActive Control2 Interventions
The myometrial samples are bathed in an oxytocin solution at increasing concentrations (from 10 -12M to 10 -9M) plus propranol (10 -6M)
Group III: Low Dose OxytocinActive Control1 Intervention
The myometrial samples are bathed in an oxytocin solution at increasing concentrations (from 10 -12M to 10 -9M)
Group IV: High Dose Oxytocin, Propranolol-pretreatedActive Control2 Interventions
The myometrial samples are bathed in an oxytocin solution (10 -5M) plus propranolol (10 -6M), followed by increasing concentrations of oxytocin (from 10 -8M to 10 -5M)
Group V: PropranololActive Control1 Intervention
The myometrial samples are bathed in a propranol solution at 10 -6M
Group VI: High Dose OxytocinActive Control1 Intervention
The myometrial samples are bathed in an oxytocin solution (10 -5M), followed by increasing concentrations of oxytocin (from 10 -8M to 10 -5M)

Find a Location

Who is running the clinical trial?

Samuel Lunenfeld Research Institute, Mount Sinai HospitalLead Sponsor
127 Previous Clinical Trials
11,180 Total Patients Enrolled
30 Trials studying Postpartum Hemorrhage
1,668 Patients Enrolled for Postpartum Hemorrhage
Mrinalini Balki, MDPrincipal InvestigatorMOUNT SINAI HOSPITAL
29 Previous Clinical Trials
1,922 Total Patients Enrolled
22 Trials studying Postpartum Hemorrhage
1,198 Patients Enrolled for Postpartum Hemorrhage

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
In Vitro Optimization of Oxytocin-induced Myometrial Contractility by Propranolol
2017. "In Vitro Optimization of Oxytocin-induced Myometrial Contractility by Propranolol". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03434444.
~8 spots leftby May 2025
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