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Vasopressin Antagonist

Conivaptan for Heart Failure

N/A
Waitlist Available
Research Sponsored by Hennepin County Medical Center, Minneapolis
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up predose, 1 hour and 4 hours post dose measured on day 1, 2, 3
Awards & highlights

Study Summary

The purpose of the study is to compare the effects of conivaptan and diuretics on renal blood flow and neurohormones.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~predose, 1 hour and 4 hours post dose measured on day 1, 2, 3
This trial's timeline: 3 weeks for screening, Varies for treatment, and predose, 1 hour and 4 hours post dose measured on day 1, 2, 3 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
renal hemodynamics renal blood flow and glomerular filtration rate
Secondary outcome measures
measure plasma neurohormone levels

Trial Design

3Treatment groups
Active Control
Group I: ConivaptanActive Control1 Intervention
Conivaptan will be given via IV bolus
Group II: FurosemideActive Control1 Intervention
Furosemide will be given via IV bolus
Group III: conivaptan and furosemideActive Control1 Intervention
on day 3 subjects will receive both study drugs

Find a Location

Who is running the clinical trial?

Hennepin County Medical Center, MinneapolisLead Sponsor
21 Previous Clinical Trials
12,312 Total Patients Enrolled
Astellas Pharma IncIndustry Sponsor
690 Previous Clinical Trials
232,031 Total Patients Enrolled
1 Trials studying Heart Failure
Steven R Goldsmith, MDStudy DirectorHennepin County Medical Center, Minneapolis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Comparing the Effects of Conivaptan and Diuretics on Plasma Neurohormones and Renal Blood Flow in Patients With Chronic Congestive Heart Failure
2009. "Comparing the Effects of Conivaptan and Diuretics on Plasma Neurohormones and Renal Blood Flow in Patients With Chronic Congestive Heart Failure". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00924014.
All > Acth > Congestive Heart Failure
~1 spots leftby Apr 2025
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